Shell-cross-linked vesicles synthesized from block copolymers of poly(D,L-lactide) and poly(N-isopropyl acrylamide) as thermoresponsive nanocontainers

Hales, M., Barner-Kowollik, C., Davis, T. P., & Stenzel, M. H. (2004) Shell-cross-linked vesicles synthesized from block copolymers of poly(D,L-lactide) and poly(N-isopropyl acrylamide) as thermoresponsive nanocontainers. Langmuir, 20(25).

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A polylactide (D,L-PLA) macroRAFT agent was prepared by utilizing a hydroxyl-functional trithiocarbonate as a coinitiator for the ring-opening polymerization. The length of the resultant polymer was controlled by the concentration of the coinitiator leading to the formation of two PLA polymers with Mn = 12500 g mol-1 (PDI = 1.46) and Mn = 20500 g mol-1 (PDI = 1.38) each with ω-trithiocarbonate functionality. Chain extension of PLA via the RAFT (free radical) polymerization of N-isopropyl acrylamide (NIPAAm) resulted in the formation of amphiphilic block copolymers with the PNIPAAm block increasing in size with conversion. TEM measurements of the aggregates obtained by self-organization of the block copolymers in aqueous solutions indicated the formation of vesicles. The sizes of these aggregates were influenced by the ratio of both blocks and the molecular weight of each block. The lower critical solution temperature (LCST) of the block copolymer was largely unaffected by the size of each block. UV turbidity measurements indicated a higher LCST for the block copolymers than for the corresponding PNIPAAm homopolymers. Stabilization of the vesicles was attained by a cross-linking chain extension of the PNIPAAm block using hexamethylene diacrylate. As the trithiocarbonate group was located between the PLA and PNIPAAm blocks, the chain extension resulted in a cross-linked layer between the core and corona of the vesicles.

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ID Code: 99087
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :146
Export Date: 5 September 2016
Correspondence Address: Stenzel, M.H.; Ctr. for Adv. Macromolecular Design, Sch. of Chem. Eng. and Indust. Chem., University of New South Wales, Sydney, NSW 2052, Australia; email:
Chemicals/CAS: polylactide, 26680-10-4; Acrylic Resins; poly(lactide), 26969-66-4; poly-N-isopropylacrylamide, 25189-55-3; Polyesters
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Keywords: Agglomeration, Biocompatibility, Cells, Crosslinking, Drug products, Hydrophilicity, Ionic strength, Micelles, Molecular weight, Polymerization, Biocompatible polymers, Opsonization, Shell-cross-linked vesicles, Thermoresponsive nanocontainers, Block copolymers, acrylic acid resin, nanomaterial, poly N isopropylacrylamide, poly-N-isopropylacrylamide, polyester, polylactide, article, chemical structure, chemistry, particle size, surface property, temperature, time, Acrylic Resins, Molecular Structure, Nanostructures, Polyesters, Surface Properties, Time Factors, Cross Linking, Polymers
DOI: 10.1021/la0484016
ISSN: 07437463
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 22 Sep 2016 04:50
Last Modified: 22 Sep 2016 04:50

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