Chemo-enzymatic synthesis and RAFT polymerization of 6-O-methacryloyl mannose: A suitable glycopolymer for binding to the tetrameric lectin concanavalin A?

Granville, A. M., Quémener, D., Davis, T. P., Barner-Kowollik, C., & Stenzel, M. H. (2007) Chemo-enzymatic synthesis and RAFT polymerization of 6-O-methacryloyl mannose: A suitable glycopolymer for binding to the tetrameric lectin concanavalin A? Macromolecular Symposia, 255.

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The chemo-enzymatic synthesis of 6-O-methacryloyl mannose (MaM) glycomonomer was successfully performed for the first time. Subsequent aqueous RAFT polymerization of the monomer yielded well-defined, linear poly(6-O-methacryloyl mannose) (PMaM) glycopolymers without the need for protecting and deprotecting group chemistry. As well as investigating the RAFT polymerization kinetics of this monomer using various initial monomer to chain transfer agent concentration ratios, the protein binding ability of the generated glycopolymer was tested using concanavalin A, a known mannose-residue binding lectin. Copyright © 2007 WILEY-VCH Verlag GmbH & Co. KGaA.

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ID Code: 99147
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :33
Export Date: 5 September 2016
Correspondence Address: Stenzel, M.H.; Centre for Advanced Macromolecular Design, School of Chemical Engineering and Industrial Chemistry, University of New South Wales, Sydney, NSW 2052, Australia; email:
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Keywords: Glycopolymer, Protein binding, RAFT polymerization, Reversible addition-fragmentation chain transfer polymerization, Binding sites, Biosynthesis, Enzymes, Monomers, Polymerization, Glucose
DOI: 10.1002/masy.200750909
ISSN: 10221360
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 22 Sep 2016 04:50
Last Modified: 06 Oct 2016 22:48

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