Synthesis of semi-biodegradable crosslinked microspheres for the delivery of 1,25 dihydroxyvitamin D3 for the treatment of hepatocellular carcinoma
Nguyen, T. L. U., Tey, S. Y., Pourgholami, M. H., Morris, D. L., Davis, T. P., Barner-Kowollik, C., & Stenzel, M. H. (2007) Synthesis of semi-biodegradable crosslinked microspheres for the delivery of 1,25 dihydroxyvitamin D3 for the treatment of hepatocellular carcinoma. European Polymer Journal, 43(5).
It has been demonstrated that 1,25 dihydroxyvitamin D3 (1,25(OH)2VD3) can inhibit the proliferation of cancer cells, including colorectal and hepatocellular cells which are mainly responsible for liver cancer. However, the use of 1,25(OH)2VD3 is hampered due to the development of hypercalcaemia. We hereby report a promising technique in liver cancer treatment by utilizing crosslinked microspheres prepared by polymerization as a carrier to control the release of 1,25(OH)2VD3 or hydrophobic drug in general at targeted sites over a long period. Microspheres in the size range of 35 μm were prepared and the drug was loaded to these poly(vinyl neodecanoate-crosslinked-ethyleneglycol dimethacrylate) microspheres after polymerization. The release study has shown that up to 1% of the drug was released after 40 days. MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay and direct contact cytotoxicity assay using HT-20 and L929 confirm the non-toxicity of these spheres. © 2007 Elsevier Ltd. All rights reserved.
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|Item Type:||Journal Article|
|Additional Information:||Cited By :8 Export Date: 5 September 2016 CODEN: EUPJA Correspondence Address: Stenzel, M.H.; Centre for Advanced Macromolecular Design (CAMD), School of Chemical Sciences and Engineering, University of New South Wales, Sydney, NSW 2052, Australia; email: firstname.lastname@example.org References: Seong, J., Keum, K.C., Han, K.H., Lee, D.Y., Lee, J.T., Chon, C.Y., Combined transcatheter arterial chemoembolization and local radiotherapy of unresectable hepatocellular carcinoma (1999) Int J Radiat Oncol, 43, pp. 393-397; De Santics, T.J., Goldberg, N.S., Mueller, R.P., Percutaneous treatment of hepatic neoplasms: a review of current techniques (1998) Cardiovas Intervent Radiol, 21, pp. 273-296; Akhter, J., Chen, X., Bowrey, P., Bolton, E.J., Morris, D.L., Vitamin D3 analog EB 1089 inhibits growth of subcutaneous xenografts of human colon cancer cell line LoVo in a nude mouse mode (1997) Dis Colon Rectum, 40, pp. 317-321; Welsh, J., Induction of apoptosis in breast cancer cells in response to vitamin D and antiestrogens (1994) Biochem Cell Biol, 72, pp. 537-545; Chouvet, C., Vicard, E., Devonec, M., Saez, S., 1,25-Dihydroxyvitamin D3 inhibitory effect on the growth of two human breast cancer cell lines (MCF-7, BT-20) (1986) J Steroid Biochem Molecular Biol, 24, pp. 373-376; Hughes, P.J., Steinmeyer, A., Chandraratna, R., Brown, G., 1α,25-dihydroxyvitamin D stimulates steroid sulphatase activity in HL60 and NB4 acute myeloid leukaemia cell lines by different receptor-mediated mechanisms (2005) J Cell Biochem, 94, pp. 1175-1189; Finlay, I.G., Stewart, G.J., Shirley, P., Woolfe, S., Pourgholami, M.H., Morris, D.L., Hepatic arterial and intravenous administration of 1,25-dihydroxyvitamin D3 - evidence of a clinically significant hepatic first-pass effect (2001) Cancer Chemother Pharmacol, 48, pp. 209-214; Finlay, I.G., Stewart, G.J., Ahkter, J., Morris, D.L., A phase one study of the hepatic arterial administration of 1,25-dihydroxyvitamin D3 for liver cancers (2001) J Gastroenterol Hepatol, 16, pp. 333-337; Ariel, I.M., Treatment of inoperable primary pancreatic and liver cancer by the intra-arterial administration of radioactive isotopes (Y90 radiating spheres) (1965) Annual Surg, 162, pp. 267-278; Meade, V.M., Burton, M.A., Gray, B.N., Distribution of different sized microspheres in experimental hepatic tumours (1987) Eur J Cancer Clin On, 23, pp. 37-41; Sinha, V.R., Trehan, A., Biodegradable microspheres for protein delivery (2003) J Control Rel, 90, pp. 261-280; Gao, J., Qian, F., Szymanski-Exner, A., Stowe, N., Haaga, J., In vivo drug distribution dynamics in thermoablated and normal rabbit livers from biodegradable polymers (2002) J Biomed Mat Res, 62, pp. 308-314; Dowding, P.J., Vincent, B., Suspension polymerisation to form polymer beads (2000) Colloid Surface A, 161, pp. 259-269; Determan, A.S., Encapsulation, stabilization, and release of BSA-FITC from polyanhydride microspheres (2004) J Control Rel, 100, pp. 97-109; Mathiowitz, E., Langer, R., Polyanhydride microspheres as drug carriers: I. Hot-melt microencapsulation (1987) J Control Rel, 5, pp. 13-22; Berkland, C., Kim, K., Pack, D.W., Fabrication of PLG microspheres with precise controlled and monodisperse size distribution (2001) J Control Rel, 73, pp. 59-74; Berkland, C., Kipper, M.J., Narasimhan, B., Kim, K., Pack, D.W., Microsphere size, precipitation kinetics, and drug distribution control drug release from biodegradable polyanhydride microspheres (2004) J Control Rel, 94, pp. 129-141; Weinstein, B., Treybal, R.E., Liquid-liquid contacting in unbaffled, agitated vessels (1973) AIChE J, 19, pp. 304-312; Jahanzad, F., Sajjadi, S., Brooks, B.W., Characteristic intervals in suspension polymerisation reactors: an experimental and modelling study (2005) Chem Eng Sci, 60, pp. 5574-5589; Ni, X., Zhang, Y., Mustafa, I., Correlation of polymer particle size with droplet size in suspension polymerisation of methylmethacrylate in a batch oscillatory-baffled reactor (1999) Chem Eng Sci, 54, pp. 841-850; Platzer, B., Klodt, R.-D., Hamann, B., Henkel, K.-D., The influence of local flow conditions on the particle size distribution in an agitated vessel in the case of suspension polymerisation of styrene (2005) Chem Eng Process, 44, pp. 1228-1236; Hopff, H., Lutz, E., Pearl polymerization of methacrylates (1958) Kunstst Plast, 5, pp. 341-344; Arshady, R., Suspension, emulsion, and dispersion polymerization: a methodological survey (1992) Colloid Polym Sci, 270, pp. 717-732; Ryabov, A.V., Smirnova, L.A., Panova, G.D., Tsareva, L.V., Effect of water on the copolymerization of methyl methacrylate with methacrylic acid (1967) Trans Khim Khim Technol, 2, p. 221; Lyoo, W.S., Park, C.S., Choi, K.H., Kwak, J.W., Yoon, W.S., Noh, S.K., Effect of suspension polymerization conditions of vinyl pivalate on the size and its distribution of poly(vinyl pivalate) microspheres (2005) Polym-Plast Tech, 44, pp. 475-487; Hohenstein, W.P., Mark, H., Polymerization of olefins and diolefins in suspension and emulsion (1946) J Polym Sci, 1, pp. 127-145; Trommsdorff, E., Kohle, H., Legally, P., Polymerization of methyl methacrylates (1948) Makromol Chem, 1, pp. 169-198; Zammit, M.D., Coote, M.L., Davis, T.P., Willett, G.D., Effect of the ester side-chain on the propagation kinetics of alkyl methacrylates - An entropic or enthalpic effect? (1998) Macromolecules, 31, pp. 955-963; Balic, R., Gilbert, R.G., Zammit, M.D., Davis, T.P., Miller, C.M., Propagation rate coefficient of vinyl neo-decanoate by pulsed laser polymerization (1997) Macromolecules, 30, pp. 3775-3780; Nguyen, L.T.U., Eagles, K., Davis, T.P., Barner-Kowollik, C., Stenzel, M.H., Investigation into the influence of the architectures of poly(vinyl pyrrolidone) polymers made via the RAFT/ MADIX mechanism on the stabilization of suspension polymerizations (2006) J Polym Sci Polym Chem, 44, p. 4372; Park, K., Yang, J.H., Choi, Y., Lee, C., Kim, S.Y., Byun, Y., Chemoprevention of 4-NQO-induced oral carcinogenesis by co-administrati on of all-trans retinoic acid loaded microspheres and celecoxib (2005) J Control Rel, 104, pp. 167-179; Zhu, H., McShane, M.J., Loading of hydrophobic materials into polymeric particles: implications for fluorescent nanosensors and drug delivery (2005) J Am Chem Soc, 127, pp. 13448-13449|
|Keywords:||1,25 Dihydroxyvitamin D3, Liver cancer, Microspheres, Suspension polymerization, Biodegradability, Cytotoxicity, Oncology, Polymerization, Synthesis (chemical), Vitamins, Hepatocellular carcinoma, Hypercalcaemia, Drug delivery|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Deposited On:||22 Sep 2016 04:50|
|Last Modified:||12 Oct 2016 04:38|
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