Acid-degradable core-crosslinked micelles prepared from thermosensitive glycopolymers synthesized via RAFT polymerization

Zhang, L., Bernard, J., Davis, T. P., Barner-Kowollik, C., & Stenzel, M. H. (2008) Acid-degradable core-crosslinked micelles prepared from thermosensitive glycopolymers synthesized via RAFT polymerization. Macromolecular Rapid Communications, 29(2).

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A thermoresponsive block copolymer, namely poly(acryloyl glucosamine)-block-poly(N-isopropylacryamide) (PAGA180-b-PNIPAAM 350) was simultaneously self-assembled and crosslinked in aqueous medium via RAFT polymerization at 60°C to afford core-crosslinked micelles exhibiting a glycopolymer corona and a PNIPAAM stimuli-responsive core. An acid-labile crosslinking agent, 3,9-divinyl-2,4,8,10-tetraoxaspiro[5.5]- undecane, was employed to generate thermosensitive and acid-degradable core-shell nanoparticles. Stable against degradation at pH = 6 and 8.2, the resulting core crosslinked micelles readily hydrolyzed into well-defined free block copolymers at lower pH (30 min and 12 h respectively at pH = 2 and 4). © 2008 WILEY-VCH Verlag GmbH & Co. KGaA.

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ID Code: 99200
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :105
Export Date: 5 September 2016
Correspondence Address: Stenzel, M.H.; Centre for Advanced Macromolecular Design (CAMD), School of Chemical Sciences and Engineering, University of New South Wales, Sydney, NSW 2052, Australia; email:
References: Duncan, R., Hume, I.C., Kopeckova, P., Ulbrich, K., Strihalm, J., Kopecek, J., (1989) J. Controlled Release, 10, p. 51; Kochetkov, N.K., (1984) Pure Appl. Chem, 56, p. 923; Ambrosi, M., Xameron, N.R., Davis, B.G., (2005) Org. Biomol. Chem, 3, p. 1593; Fazio, F., Bryan, M.C., Blixt, O., Paulson, J.C., Wong, C.H., (2002) J. Am. Chem. Soc, 124, p. 14397; Dove, A., (2001) Nat. Biotechnol, 19, p. 913; Kiessling, L.L., Cairo, C.W., (2002) Nat. Biotechnol, 20, p. 234; Dwek, R.A., (1996) Chem. Rev, 96, p. 683; Tirrell, D.A., (2004) Nature, 430, p. 837; Sharon, N., Lis, H., (1993) Sci. Am, 268, p. 82; Spain, S.G., Gibson, M.I., Cameron, N.R., (2007) Polym. Sci., Part A: Polym. Chem, 45, p. 2059; Schnaar, R.L., Immobilized glycoconjugates for cell recognition (1994) Neoglycoconjugates: Preparation and Applications, p. 425. , Y. C. Lee, R. T. Lee, Eds, Acdemic Press, New York; Weigel, P.H., Schnaar, R.L., Kuhelnschmidet, M.S., Schmell, E., Lee, R.T., Lee, Y.C., Roseman, S., (1979) J. Biol. Chem, 254, p. 10830; Lundquist, J.J., Toone, E.J., (2002) Chem. Rev, 102, p. 555; Wang, Q., Dordick, J.S., Linhardt, R., (2002) J. Chem. Mater, 14, p. 3232; Toyokuni, T., Singhal, A.K., (1995) Chem. Soc. Rev, 24, p. 231; O'Hare, K.B., Hume, I.C., Scarlett, L., Chytrý, V., Kopećarková, P., Kopeček, J., Duncan, R., (1989) Hepatology, 10, p. 207; Lavasanifar, A., Samuel, J., Kwon, J.S., (2002) Adv. Drug Delivery Rev, 54, p. 169; Thurmond, K.B., Kowalewski, T., Wooley, K.L., (1996) J. Am. Chem. Soc, 118, p. 7239; O'Reilly, R.K., Hawker, C.J., Wooley, K.L., (2006) Chem. Soc. Rev, 35, p. 1068; O'Reilly, R.K., Joralemon, M.J., Hawker, C.J., Wooley, K.L., (2006) J. Polym. Sci., Part A: Polym. Chem, 44, p. 5203; Iijima, M., Nagasaki, Y., Okada, T., Kato, M., Kataoka, K., (1999) Macromolecules, 32, p. 1140; Emoto, K., Nagasaki, Y., Kataoka, K., (1999) Langmuir, 15, p. 5212; Won, Y.Y., Davis, H.T., Bates, F.S., (1999) Science, 283, p. 960; Ladmiral, V., Melia, E., Haddleton, D.M., (2004) Eu. Polymer. J, 40, p. 431; S. G. Spain, M. I. Gibson, N. R. Cameron, J. Polym. Sci., Part A: Polym. Chem. 2007, 45, 2059Loykulnant, S., Hirao, A., (2000) Macromolecules, 33, p. 4757; Bernard, J., Schappacher, M., Deffieux, A., Charles, M.H., Charreyre, M.T., Delair, T., Viville, P., Lazzaroni, R., (2006) Bioconjugate Chem, 6, p. 17; Aoi, K., Tsutsumiuchi, K., Okada, M., (1994) Macromolecules, 27, p. 875; Tsutsumiuchi, K., Aoi, K., Okada, M., (1997) Macromolecules, 30, p. 4013; Mortell, K.H., Gingras, M., Kiessling, L.L., (1994) J. Am. Chem. Soc, 116, p. 12053; Fraser, C., Grubbs, R.H., (1995) Macromolecules, 28, p. 7248; Ting, S., Quemener, D., Granville, A., Davis, T.P., Stenzel, M.H., Barner-Kowollik, C., (2007) Aust. J. Chem, 60, p. 405; Ladmiral, V., Mantovani, G., Clarkson, G.J., Cauet, S., Irwin, J.L., Haddleton, D.M., (2006) J. Am. Chem. Soc, 128, p. 4823; Hou, S., Sun, X.L., Dong, C.M., Chaikof, E.L., (2004) Bioconjugate Chem, 15, p. 954; Sun, X.L., Faucher, K.M., Houston, M., Grande, D., Chaikof, E.L., (2002) J. Am. Chem. Soc, 124, p. 7258; Grande, D., Baskaran, S., Baskaran, C., Gnanou, Y., Chaikof, E.L., (2000) Macromolecules, 33, p. 1123; Matyjaszewski, K., Xia, J., (2001) Chem. Rev, 101, p. 2921; WO9630421 1996, invs, K. Matyjaszewski, J. S. Wang; PCT Int. ApplHawker, C.J., Bosman, A.W., Harth, E., (2001) Chem. Rev, 101, p. 3661; Narain, R., Armes, S.P., (2003) Macromolecules, 36, p. 4675; Narain, R., Armes, S.P., (2003) Biomacromolecules, 4, p. 1746; Barner, L., Davis, T.P., Stenzel, M.H., Barner-Kowollik, C., (2007) Macromol. Rapid Commun, 28, p. 539; Chong, Y.K., Tam, P.T., Moad, G., Rizzardo, E., Thang, S.H., (1999) Macromolecules, 32, p. 2071; Lowe, A.B., Sumerlin, B.S., McCormick, C.L., (2003) Polymer, 44, p. 6761; Albertin, L., Stenzel, M.H., Barner-Kowollik, C., Foster, L.J.R., Davis, T.P., (2004) Macromolecules, 37, p. 7530; Özyürek, Z., Komber, H., Gramm, S., Schmaljohann, D., Müller, A.H.E., Voit, B., (2007) Macromol. Chem. Phys, 208, p. 1035; Bernard, J., Hao, X., Davis, T.P., Barner-Kowollik, C., Stenzel, M.H., (2006) Biomacromolecules, 7, p. 232; Lowe, A.B., Wang, R., (2007) Polymer, 48, p. 2221; Zhang, L., Katapodi, K., Davis, T.P., Barner-Kowollik, C., Stenzel, M.H., (2006) J. Polym. Sci., Part A: Polym. Chem, 44, p. 2177; Zheng, Q., Zheng, G.H., Pan, C.Y., (2006) Polym. Int, 55, p. 1114; Yang, L.P., Pan, C.Y., (2006) Aust. J. Chem, 59, p. 733; Zhang, L., Nguyen, T.L.U., Bernard, J., Davis, T.P., Barner-Kowollik, C., Stenzel, M.H., (2007) Biomacromolecules, 8, p. 2890; Hales, M., Barner-Kowollik, C., Davis, T.P., Stenzel, M.H., (2004) Langmuir, 20, p. 10809; Murthy, N., Xu, M., Schuck, S., Kunisawa, J., Shastri, N., Frechet, J.M.J., (2003) Proc. Natl. Acad. Sci, 100, p. 4995; Kwon, Y.J., Standley, S.M., Goh, S.L., Frechet, J.M.J., (2005) J. Contr. Rel, 105, p. 199; Bulmus, V., Chan, Y., Nguyen, Q., Tran, H.L., (2007) Macromol. Bioscience, 7, p. 446; Vasilieva, Y.A., Thomas, D.B., Scales, C.W., McCormick, C.L., (2004) Macromolecules, 37, p. 2728; Guo, A., Liu, G., Tao, J., (1996) Macromolecules, 29, p. 2487; Zhou, J., Li, Z., Liu, G., (2002) Macromolecules, 35, p. 3690; Whittaker, M.R., Monteiro, M.J., (2006) Langmuir, 22, p. 9746; Lambeth, R.H., Ramakrishnan, S., Mueller, R., Poziemski, J.P., Miguel, G.S., Markoski, L.J., Zukoski, C.F., Moore, J.S., (2006) Langmuir, 22, p. 6352; Kohori, F., Sakai, K., Aoyagi, T., Yokoyama, M., Sakurai, Y., Okano, T., (1998) J. Controlled Release, 55, p. 87; Li, Z.C., Liang, Y.Z., Li, F.M., (2002) New J. Chem, 26, p. 1805; Bergsma, M., Fielden, M.L., Engberts, J.B.F.N., (2001) J. Colloid Interface Sci, 243, p. 491
Keywords: Acid-degradable, Crosslinked micelle, Glycopolymer, Reversible addition fragmentation chain transfer (RAFT), Stimulisensitive polymers, Block copolymers, Crosslinking, Polymerization, Self assembly, Synthesis (chemical), Crosslinked micelles, Micelles
DOI: 10.1002/marc.200700663
ISSN: 10221336
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 22 Sep 2016 04:50
Last Modified: 10 Oct 2016 01:14

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