Modulation of the thermoresponsive behavior of poly(N,N-diethylacrylamide) via cyclodextrin host/guest interactions

Schmidt, B. V. K. J., Hetzer, M., Ritter, H., & Barner-Kowollik, C. (2013) Modulation of the thermoresponsive behavior of poly(N,N-diethylacrylamide) via cyclodextrin host/guest interactions. Macromolecular Rapid Communications, 34(16).

View at publisher


The modulation of the cloud point of aqueous poly(N,N-diethylacrylamide) solutions via the formation of supramolecular cyclodextrin complexes with hydrophobic end groups, namely adamantyl, tert-butyl phenyl and azobenzene, synthesized via RAFT polymerization is described. The dependence of the apparent cloud points after cyclodextrin complexation is investigated with respect to the type and quantity of the guest end group, the polymer chain length and the cyclodextrin/end group ratio. Furthermore, the effect is reversed via the addition of guest molecules or via biocompatible enzymatic degradation of the cyclodextrins entire. The modulation of the cloud point of poly(N,N- diethylacrylamide) in aqueous solution via the formation of supramolecular cyclodextrin-based host/guest complexes is presented as well as the reversal of the effect via addition of competing guest molecules or biocompatible enzymatic degradation of the cyclodextrins. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Impact and interest:

21 citations in Scopus
20 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 99364
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :17
Export Date: 5 September 2016
Correspondence Address: Ritter, H.; Lehrstuhl für Präparative Polymerchemie, Institut für Organische Chemie und Makromolekulare Chemie, Heinrich-Heine Universität, Universitätsstr. 1, Geb. 26.33.00, 40225 Düsseldorf, Germany; email:
Chemicals/CAS: cyclodextrin, 12619-70-4; water, 7732-18-5
Funding Details: DFG, Deutsche Forschungsgemeinschaft
References: Alarcon, D.L.C.H., Pennadam, S., Alexander, C., (2005) Chem. Soc. Rev., 34, p. 276; Liu, F., Urban, M.W., (2010) Prog. Polym. Sci., 35, p. 3; Li, Y., Lokitz, B.S., McCormick, C.L., (2006) Angew. Chem., Int. Ed., 45, p. 5792; Roy, D., Brooks, W.L.A., Sumerlin, B.S., (2013) Chem. Soc. Rev.; Schmaljohann, D., (2006) Adv. Drug Delivery Rev., 58, p. 1655; York, A.W., Kirkland, S.E., McCormick, C.L., (2008) Adv. Drug Delivery Rev., 60, p. 1018; Hoogenboom, R., Thijs, H.M.L., Jochems, M.J.H.C., Van Lankvelt, B.M., Fijten, M.W.M., Schubert, U.S., (2008) Chem. Commun., p. 5758; Lutz, J.-F., (2011) Adv. Mater., 23, p. 2237; Hirokawa, Y., Tanaka, T., (1984) J. Chem. Phys., 81, p. 6379; Glatzel, S., Laschewsky, A., Lutz, J.-F., (2010) Macromolecules, 44, p. 413; Meiswinkel, G., Ritter, H., (2013) Macromol. Rapid Commun., 34, p. 1026; Idziak, I., Avoce, D., Lessard, D., Gravel, D., Zhu, X.X., (1999) Macromolecules, 32, p. 1260; Li, H., Yu, B., Matsushima, H., Hoyle, C.E., Lowe, A.B., (2009) Macromolecules, 42, p. 6537; Zhao, Y., Tremblay, L., Zhao, Y., (2011) Macromolecules, 44, p. 4007; Ritter, H., Sadowski, O., Tepper, E., (2003) Angew. Chem., Int. Ed., 42, p. 3171; Duan, Q., Miura, Y., Narumi, A., Shen, X., Sato, S.-I., Satoh, T., Kakuchi, T., (2006) J. Polym. Sci., Part A: Polym. Chem., 44, p. 1117; Maatz, G., Maciollek, A., Ritter, H., (2012) Beilstein J. Org. Chem., 8, p. 1929; Rauwald, U., Barrio, J.D., Loh, X.J., Scherman, O.A., (2011) Chem. Commun., 47, p. 6000; Summers, M.J., Phillips, D.J., Gibson, M.I., (2013) Chem. Commun., 49, p. 4223; Jochum, F.D., Zur Borg, L., Roth, P.J., Theato, P., (2009) Macromolecules, 42, p. 7854; Schmidt, B.V.K.J., Hetzer, M., Ritter, H., Barner-Kowollik, C., (2011) Macromolecules, 44, p. 7220; Schmidt, B.V.K.J., Rudolph, T., Hetzer, M., Ritter, H., Schacher, F.H., Barner-Kowollik, C., (2012) Polym. Chem., 3, p. 3139; Schmidt, B.V.K.J., Hetzer, M., Ritter, H., Barner-Kowollik, C., (2013) Macromolecules, 46, p. 1054; Schmidt, B.V.K.J., Hetzer, M., Ritter, H., Barner-Kowollik, C., (2012) Polym. Chem., 3, p. 3064; Höfler, T., Wenz, G., (1996) J. Inclusion Phenom. Macrocyclic Chem., 25, p. 81; Rekharsky, M.V., Inoue, Y., (1998) Chem. Rev., 98, p. 1875; Gan, L.H., Cai, W., Tam, K.C., (2001) Eur. Polym. J., 37, p. 1773
Keywords: cyclodextrins, LCST, RAFT polymerization, thermoresponsive polymers, Cyclodextrin complexes, Enzymatic Degradation, Poly(N , N-diethylacrylamide), Polymer chain length, Thermo-responsive behaviors, Thermoresponsive polymer, Biocompatibility, Chain length, Living polymerization, Modulation, Molecules, Polymers, Supramolecular chemistry, Synthesis (chemical), acrylamide derivative, beta cyclodextrin derivative, cyclodextrin, methyl beta cyclodextrin, methyl-beta-cyclodextrin, poly(N,N diethylacrylamide), poly(N,N-diethylacrylamide), polymer, water, article, chemical phenomena, chemistry, Acrylamides, beta-Cyclodextrins, Hydrophobic and Hydrophilic Interactions
DOI: 10.1002/marc.201300478
ISSN: 10221336
Divisions: Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 22 Sep 2016 04:50
Last Modified: 28 Jun 2017 16:02

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page