Photochemical design of functional fluorescent single-chain nanoparticles

Willenbacher, J., Wuest, K. N. R., Mueller, J. O., Kaupp, M., Wagenknecht, H. A., & Barner-Kowollik, C. (2014) Photochemical design of functional fluorescent single-chain nanoparticles. ACS Macro Letters, 3(6).

View at publisher


We report the facile ambient temperature generation of size tunable and well-defined (pro)fluorescent single-chain nanoparticles (SCNPs) via the photoinduced nitrile imine intramolecular cross-ligation of linear precursor polymers, constituting a platform technology as novel imaging agents. A set of three linear precursor polymers (Mn ≈ 14000 g mol -1,≈ 1.25) was synthesized via nitroxide-mediated statistical copolymerization of styrene and 4-(chloromethyl)styrene (CMS), followed by a postpolymerization modification of the resulting copolymer installing protected maleimide (PG-Mal) as well as tetrazole (Tet) moieties. The tetrazole content (% Tet) along the lateral polymer chains was varied between 12 and 24% in order to preselect not only the size of the corresponding SCNPs, but also their fluorescence and reactive properties. Finally, the applicability of the profluorescent SCNPs for fluorescence labeling was demonstrated utilizing residual surface expressed Tet moieties on the SCNPs surface in a reaction with maleimide functional polymeric microspheres. The (pro)fluorescent single-chain nanoparticles were in-depth characterized by 1H NMR spectroscopy, dynamic light scattering (DLS), size exclusion chromatography (SEC), and atomic force microscopy (AFM), as well as UV/vis and fluorescence spectroscopy. © 2014 American Chemical Society.

Impact and interest:

27 citations in Scopus
Search Google Scholar™
27 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 99416
Item Type: Journal Article
Refereed: Yes
Additional Information: Cited By :26
Export Date: 5 September 2016
Correspondence Address: Barner-Kowollik, C.; Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology (KIT), Engesserstr. 18, 76131 Karlsruhe, Germany; email:
References: Altintas, O., Barner-Kowollik, C., (2012) Macromol. Rapid Commun., 33, pp. 958-971; Ouchi, M., Badi, N., Lutz, J.-F., Sawamoto, M., (2011) Nat. Chem., 3, pp. 917-924; Sanchez-Sanchez, A., Pomposo, J.A., (2014) Part. Part. Syst. Charact., 31, pp. 11-23; Altintas, O., Lejeune, E., Gerstel, P., Barner-Kowollik, C., (2012) Polym. Chem., 3, pp. 640-651; Willenbacher, J., Altintas, O., Roesky, P.W., Barner-Kowollik, C., (2013) Macromol. Rapid Commun., 35, pp. 45-51; Schmidt, B.V.K.J., Fechler, N., Falkenhagen, J., Lutz, J.-F., (2011) Nat. Chem., 3, pp. 234-238; Hosono, N., Gillissen, M.A.J., Li, Y., Sheiko, S.S., Palmans, A.R.A., Meijer, E.W., (2012) J. Am. Chem. Soc., 135, pp. 501-510; Appel, E.A., Dyson, J., Del Barrio, J., Walsh, Z., Scherman, O.A., (2012) Angew. Chem., Int. Ed., 51, pp. 4185-4189; Murray, B.S., Fulton, D.A., (2011) Macromolecules, 44, pp. 7242-7252; Tuten, B.T., Chao, D., Lyon, C.K., Berda, E.B., (2012) Polym. Chem., 3, pp. 3068-3071; Oria, L., Aguado, R., Pomposo, J.A., Colmenero, J., (2010) Adv. Mater., 22, pp. 3038-3041; Chao, D., Jia, X., Tuten, B., Wang, C., Berda, E.B., (2013) Chem. Commun., 49, pp. 4178-4180; Sanchez-Sanchez, A., Akbari, S., Etxeberria, A., Arbe, A., Gasser, U., Moreno, A.J., Colmenero, J., Pomposo, J.A., (2013) ACS Macro Lett., 2, pp. 491-495; Altintas, O., Willenbacher, J., Wuest, K.N.R., Oehlenschlaeger, K.K., Krolla-Sidenstein, P., Gliemann, H., Barner-Kowollik, C., (2013) Macromolecules, 46, pp. 8092-8101; He, J., Tremblay, L., Lacelle, S., Zhao, Y., (2011) Soft Matter, 7, pp. 2380-2386; Frank, P.G., Tuten, B.T., Prasher, A., Chao, D., Berda, E.B., (2014) Macromol. Rapid Commun., 35, pp. 249-253; Clovis, J.S., Eckell, A., Huisgen, R., Sustmann, R., (1967) Chem. Ber., 100, pp. 60-70; Song, W., Wang, Y., Qu, J., Lin, Q., (2008) J. Am. Chem. Soc., 130, pp. 9654-9655; Mueller, J.O., Guimard, N.K., Oehlenschlaeger, K.K., Schmidt, F.G., Barner-Kowollik, C., (2014) Polym. Chem., 5, pp. 1447-1456; Blasco, E., Pinol, M., Oriol, L., Schmidt, B.V.K.J., Welle, A., Trouillet, V., Bruns, M., Barner-Kowollik, C., (2013) Adv. Funct. Mater., 23, pp. 4011-4019; De Hoog, H.-P.M., Nallani, M., Liedberg, B., (2012) Polym. Chem., 3, pp. 302-306; Wang, J., Zhang, W., Song, W., Wang, Y., Yu, Z., Li, J., Wu, M., Lin, Q., (2010) J. Am. Chem. Soc., 132, pp. 14812-14818; Madden, M.M., Rivera Vera, C.I., Song, W., Lin, Q., (2009) Chem. Commun., pp. 5588-5590; Dürr, C.J., Lederhose, P., Hlalele, L., Abt, D., Kaiser, A., Brandau, S., Barner-Kowollik, C., (2013) Macromolecules, 46, pp. 5915-5923; De Luzuriaga, A.R., Ormategui, N., Grande, H.J., Odriozola, I., Pomposo, J.A., Loinaz, I., (2008) Macromol. Rapid Commun., 29, pp. 1156-1160; Rabani, E., Reichman, D.R., Geissler, P.L., Brus, L.E., (2003) Nature, 426, pp. 271-274; Van Roekel, H.W.H., Stals, P.J.M., Gillissen, M.A.J., Hilbers, P.A.J., Markvoort, A.J., De Greef, T.F.A., (2013) Chem. Commun., 49, pp. 3122-3124; Berda, E.B., Foster, E.J., Meijer, E.W., (2010) Macromolecules, 43, pp. 1430-1437; Fetters, L.J., Hadjichristidis, N., Lindner, J.S., Mays, J.W., (1994) J. Phys. Chem. Ref. Data, 23, pp. 619-640; Kaupp, M., Tischer, T., Hirschbiel, A.F., Vogt, A.P., Geckle, U., Trouillet, V., Hofe, T., Barner-Kowollik, C., (2013) Macromolecules, 46, pp. 6858-6872
DOI: 10.1021/mz500292e
ISSN: 21611653
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 22 Sep 2016 04:50
Last Modified: 27 Sep 2016 01:04

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page