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Evaluation of inner retinal function in myopia using oscillatory potentials of the multifocal electroretinogram

Chen, Jennifer C., Brown, Brian, & Schmid, Katrina L. (2006) Evaluation of inner retinal function in myopia using oscillatory potentials of the multifocal electroretinogram. Vision Research, 46(24), pp. 4096-4103.

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Abstract

Purpose: Oscillatory potentials have been suggested to arise frorri the inner retina at the level of amacrine cells and inner plexiform layer and they are thought to provide a non-invasive assessment of inner retinal function. We sought to investigate the response dynamics of the inner retina of adult ernmetropes and myopes by analysing the oscillatory potentials of the multifocal electroretinograin (mfERG) in these groups. Methods: Eleven emmetropes and 18 myopes underwent mfERG testing using VERIS 5.1.5X. Myopes were further separated based on whether their myopia was stable (n = 9) or progressing (n = 9). Oscillatory potentials were recorded using a modified mfERG stimulation technique, the slow flash paradigm, and they were extracted using band-pass filtering from 100 to 300 Hz. The slow flash mfERG stimulus array consisted of 103-scaled hexagons and flickered according to a pseudorandom binary m-sequence (2(13-)1). Amplitudes and implicit times of the first-order oscillatory potentials were analysed. Results: There were significant differences in the implicit time of the oscillatory potentials of the emmetropes, stable myopes and progressing myopes (F-2,F-25 = 3.663, p = 0.043). Progressing myopes had significantly shorter implicit times compared to emmetropes (p = 0.026 by 1.0-4.7 ms) and stable myopes (p = 0.043 by 0.8-1.3 ms), whereas implicit times of stable myopes and emmetropes were similar. There were no statistically significant differences in amplitude of the oscillatory potentials between the groups (F-2,F-25 = 0-890, p = 0.426). Conclusions: Significant differences in multifocal oscillatory potentials between stable and progressing myopes were found. This finding is further evidence of an inner retinal involvement in human myopia progression and may suggest an underlying alteration to dopaminergic or GABAergic retinal systems.

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5 citations in Web of Science®

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ID Code: 9943
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
Keywords: myopia, multifocal electroretinogram, mfERG, oscillatory potentials, slow flash mfERG, refractive error KeyWords Plus, FORM, DEPRIVATION MYOPIA, EARLY DIABETIC, RETINOPATHY, SLOW, SEQUENCE MFERG, EYE GROWTH, CHEMICAL, SENSITIVITY, ERG, DOPAMINE, CHICK, COMPONENTS, FLASH
DOI: 10.1016/j.visres.2006.07.033
ISSN: 0042-6989
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Divisions: Current > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Elsevier
Deposited On: 04 Oct 2007
Last Modified: 29 Feb 2012 23:23

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