A disulfide intercalator toolbox for the site-directed modification of polypeptides
Wang, T., Wu, Y., Kuan, S. L., Dumele, O., Lamla, M., Ng, D. Y. W., Arzt, M., Thomas, J., Mueller, J. O., Barner-Kowollik, C., & Weil, T. (2015) A disulfide intercalator toolbox for the site-directed modification of polypeptides. Chemistry: A European Journal, 21(1), pp. 228-238.
A disulfide intercalator toolbox was developed for site-specific attachment of a broad variety of functional groups to proteins or peptides under mild, physiological conditions. The peptide hormone somatostatin (SST) served as model compound for intercalation into the available disulfide functionalization schemes starting from the intercalator or the reactive SST precursor before or after bioconjugation. A tetrazole-SST derivative was obtained that undergoes photoinduced cycloaddition in mammalian cells, which was monitored by live-cell imaging. © 2015 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|Item Type:||Journal Article|
|Keywords:||Disulfides, Imaging agents, Intercalation, Peptides, Somatostatin, Functional groups, Intercalation compounds, Mammals, Proteins, Directed modifications, Functionalizations, Imaging agent, Live-cell imaging, Peptide hormones, Physiological condition, Sulfur compounds|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim|
|Deposited On:||22 Sep 2016 04:50|
|Last Modified:||26 Sep 2016 06:30|
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