Stepwise Unfolding of Single-Chain Nanoparticles by Chemically Triggered Gates

Fischer, T. S., Schulze-Sünninghausen, D., Luy, B., Altintas, O., & Barner-Kowollik, C. (2016) Stepwise Unfolding of Single-Chain Nanoparticles by Chemically Triggered Gates. Angewandte Chemie - International Edition.

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The orthogonal, stepwise, and order-independent unfolding of single-chain nanoparticles (SCNPs) is introduced as a key step towards actively controlling the folding dynamics of SCNPs. The SCNPs are compacted by multiple hydrogen bonds and host-guest interactions. Well-defined diblock (AB) and tetrablock (ABCD) copolymers are equipped with orthogonal recognition motifs via modular ligation along the lateral chain. Initially, single-chain folding of the diblock copolymer was induced by the host-guest complexation of benzo-21-crown-7 (B21C7, host) and a secondary ammonium salt (AS, guest), representing an efficient avenue for single-chain collapse. Next, both orthogonal Hamilton wedge (HW) and cyanuric acid (CA) as well as B21C7-AS motifs were employed to generate SCNPs based on the ABCD polymer system. Subsequently, the stepwise dual-gated and order-independent unfolding of the SCNPs was investigated by the addition of external stimuli. The folding and unfolding were explored by 1D 1HNMR spectroscopy, dynamic light scattering (DLS), and diffusion-ordered NMR spectroscopy (DOSY). © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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ID Code: 99461
Item Type: Journal Article
Refereed: Yes
Additional Information: Export Date: 5 September 2016
Article in Press
Correspondence Address: Altintas,
Keywords: Host-guest interactions, Orthogonal unfolding, Polymer synthesis, Single-chain folding, Supramolecular chemistry, Complexation, Dynamic light scattering, Hydrogen bonds, Light scattering, Nanoparticles, Nuclear magnetic resonance spectroscopy, Reconfigurable hardware, Diffusion ordered NMR spectroscopies, Folding and unfolding, Host guest interactions, Host-guest complexations, Order independents, Single chains, Chains
DOI: 10.1002/anie.201602894
ISSN: 14337851
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute for Future Environments
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 22 Sep 2016 04:50
Last Modified: 23 Sep 2016 02:44

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