Changes in implicit time of the multifocal electroretinogram response following contrast adaptation

Chen, Jennifer C., Brown, Brian, & Schmid, Katrina L. (2006) Changes in implicit time of the multifocal electroretinogram response following contrast adaptation. Current Eye Research, 31(6), pp. 549-556.

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Purpose : Contrast adaptation, produced by prolonged viewing of high contrast gratings, has been suggested to occur at both retinal and cortical locations within the visual pathway. We sought to investigate the characteristics of retinal contrast adaptation using the multifocal electroretinogram (mfERG). Methods : Twenty subjects, with a mean age of 27.8 +/- 5.3 years, underwent mfERG testing using VERIS I. The mfERG was measured after 10 minutes of adaptation to 94% contrast, 5 cyc/deg, sinusoidal, vertical gratings and to an equi-luminance blank control. The mfERG stimulus array consisted of 61-scaled hexagons and flickered according to a pseudorandom binary m-sequence (2(13) -1). Changes in amplitude and implicit time of the first-order kernel were analyzed to determine the effect of contrast adaptation on retinal responses. Results : Adaptation to the vertical grating pattern produced a 2.5 ms increase in implicit time, and the response delay was greatest in the more peripheral parts of the retina (7.6 degrees to 30 degrees). Contrast adaptation did not produce statistically significant changes to the amplitude of the mfERG waveform. Conclusions : Contrast adaptation produced by prolonged viewing of high contrast gratings had a significant effect on retinal responses. It has been suggested that contrast adaptation may play a role in the development of nearwork induced myopia; further work investigating retinal contrast adaptation in myopic individuals may be of interest.

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6 citations in Web of Science®
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ID Code: 9951
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
Keywords: contrast adaptation, multifocal electroretinogram, mfERG, retina, human KeyWords Plus, DIABETIC, RETINOPATHY, RETINAL DYSFUNCTION, VISUAL, CORTEX, SPATIAL SCALE, ERG, TOPOGRAPHY, LUMINANCE, CELLS, MFERG, ORIENTATION
DOI: 10.1080/02713680600744869
ISSN: 0271-3683
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Vision Science (111303)
Divisions: Past > Research Centres > Centre for Health Research
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2006 Taylor & Francis
Copyright Statement: First published in Current Eye Research 31(6):pp. 549-556.
Deposited On: 04 Oct 2007 00:00
Last Modified: 29 Feb 2012 13:23

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