The dopamine hypothesis of schizophrenia: Current status

Gründer, Gerhard & Cumming, Paul (2016) The dopamine hypothesis of schizophrenia: Current status. In Abel, Ted & Nickl-Jockschat, Thomas (Eds.) The Neurobiology of Schizophrenia. Academic Press, pp. 109-124.

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Abstract

The dopamine hypothesis of schizophrenia, which was formulated in the 1960s after the discovery of the antipsychotic actions of chlorpromazine, was extremely successful as a heuristic principle for interpreting aspects of the phenomenology of schizophrenia. The development of improved antipsychotic medications was guided by a search for dopamine blockers based on the concept that schizophrenia is, in part, a hyperdopaminergic state. Molecular imaging studies performed over the past 25 years strongly support an association of increased subcortical dopamine transmission with the positive symptoms of schizophrenia, with the caveat that this finding is not pathognomonic due to neurochemical heterogeneity of populations of schizophrenia patients. Although subcortical hyperdopaminergia contributes importantly to aberrant salience (manifesting in positive symptoms), the original dopamine hypothesis must be extended to include contributions of other neurotransmitter systems, with glutamate being particularly implicated in the pathophysiology of schizophrenia.

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ID Code: 99617
Item Type: Book Chapter
Additional URLs:
Keywords: Dopamine; glutamate; positron emission tomography (PET); molecular imaging; antipsychotic; ketamine
DOI: 10.1016/B978-0-12-801829-3.00015-X
ISBN: 9780128018774
Subjects: Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) (170101)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Schools > School of Psychology & Counselling
Deposited On: 04 Oct 2016 02:11
Last Modified: 22 Nov 2016 05:12

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