Polylactides in additive biomanufacturing

Poh, Patrina S.P., Chhaya, Mohit P., Wunner, Felix M., De-Juan-Pardo, Elena M., Schilling, Arndt F., Schantz, Jan-Thorsten, van Griensven, Martijn, & Hutmacher, Dietmar W. (2016) Polylactides in additive biomanufacturing. Advanced Drug Delivery Reviews. (In Press)

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New advanced manufacturing technologies under the alias of additive biomanufacturing allow the design and fabrication of a range of products from pre-operative models, cutting guides and medical devices to scaffolds. The process of printing in 3 dimensions of cells, extracellular matrix (ECM) and biomaterials (bioinks, powders, etc.) to generate in vitro and/or in vivo tissue analogue structures has been termed bioprinting. To further advance in additive biomanufacturing, there are many aspects that we can learn from the wider additive manufacturing (AM) industry, which have progressed tremendously since its introduction into the manufacturing sector. First, this review gives an overview of additive manufacturing and both industry and academia efforts in addressing specific challenges in the AM technologies to drive toward AM-enabled industrial revolution. After which, considerations of poly(lactides) as a biomaterial in additive biomanufacturing are discussed. Challenges in wider additive biomanufacturing field are discussed in terms of (a) biomaterials; (b) computer-aided design, engineering and manufacturing; (c) AM and additive biomanufacturing printers hardware; and (d) system integration. Finally, the outlook for additive biomanufacturing was discussed.

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ID Code: 99647
Item Type: Review
Refereed: Yes
Keywords: 3D printing, Additive manufacturing, Bioprinting, Computer-aided design, Computer-aided engineering, Computer-aided manufacturing, Poly(lactic acids), Tissue engineering and regenerative medicine
DOI: 10.1016/j.addr.2016.07.006
ISSN: 0169-409X
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MANUFACTURING ENGINEERING (091000) > CAD/CAM Systems (091001)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MANUFACTURING ENGINEERING (091000) > Manufacturing Engineering not elsewhere classified (091099)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2016 Elsevier
Deposited On: 04 Oct 2016 04:20
Last Modified: 11 Oct 2016 04:57

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