Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo

Wallace, D.F. & Subramaniam, V.N. (2015) Analysis of IL-22 contribution to hepcidin induction and hypoferremia during the response to LPS in vivo. International Immunology, 27(6), pp. 281-287.

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The anaemia of chronic disease (ACD) results from inflammation-mediated up-regulation of the iron regulatory hormone hepcidin, with the consequent sequestration of iron limiting its availability for erythropoiesis. The inflammatory cytokine IL-6, a regulator of hepcidin, has been implicated in this process. Recent in vivo and in vitro studies indicate that IL-22 is also able to stimulate hepcidin expression. We aimed to determine if IL-22 had a role in causing the hypoferremia associated with the inflammatory response. Wild-type and Il22-knockout mice were subjected to an acute inflammatory stimulus via administration of LPS and the response of hepcidin and iron homeostasis was analysed. In the absence of IL-22, there was a response of hepcidin, resulting in a reduction in serum iron levels. However, the hypoferremic response to LPS was slightly blunted in mice lacking IL-22, suggesting that, during LPS-mediated inflammation, IL-22 may play a minor role in mediating the hypoferremic response. These results may have implications for the treatment and management of the ACD.

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ID Code: 99752
Item Type: Journal Article
Refereed: Yes
Keywords: gamma interferon; hepcidin; interleukin 10; interleukin 12p70; interleukin 22; interleukin 6; iron; lipopolysaccharide; messenger RNA; monocyte chemotactic protein 1; orosomucoid; prohepcidin; serum amyloid A; STAT3 protein; transferrin; tumor necrosis fa, animal experiment; animal model; animal tissue; Article; cell infiltration; cytokine production; homeostasis; hypoferremia; in vitro study; in vivo study; inflammation; iron blood level; iron metabolism disorder; liver homogenate; mouse; nonhuman; priorit
DOI: 10.1093/intimm/dxu144
ISSN: 1460-2377
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: © The Japanese Society for Immunology. 2015
Deposited On: 12 Oct 2016 02:43
Last Modified: 14 Oct 2016 04:09

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