Hepcidin: Regulation of the master iron regulator

Rishi, G., Wallace, D.F., & Subramaniam, V.N. (2015) Hepcidin: Regulation of the master iron regulator. Bioscience Reports, 35(3), Article Number-e00192.

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Abstract

Iron, an essential nutrient, is required for many diverse biological processes. The absence of a defined pathway to excrete excess iron makes it essential for the body to regulate the amount of iron absorbed; a deficiency could lead to iron deficiency and an excess to iron overload and associated disorders such as anaemia and haemochromatosis respectively. This regulation is mediated by the iron-regulatory hormone hepcidin. Hepcidin binds to the only known iron export protein, ferroportin (FPN), inducing its internalization and degradation, thus limiting the amount of iron released into the blood. The major factors that are implicated in hepcidin regulation include iron stores, hypoxia, inflammation and erythropoiesis. The present review summarizes our present knowledge about the molecular mechanisms and signalling pathways contributing to hepcidin regulation by these factors.

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26 citations in Scopus
19 citations in Web of Science®
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ID Code: 99753
Item Type: Journal Article
Refereed: Yes
Keywords: bone morphogenetic protein; bone morphogenetic protein receptor; cyclic AMP responsive element binding protein; erythropoietin; ferroportin; growth differentiation factor 15; hemojuvelin; hepcidin; hypoxia inducible factor; hypoxia inducible factor 1alpha, apoptosis; arthropathy; cardiomyopathy; cell differentiation; cell proliferation; diabetes mellitus; down regulation; erythroid cell; erythropoiesis; Fam132b gene; fatigue; gastrulation; gene; gene mutation; hemochromatosis; human; hypogonadism; hypoxia;
DOI: 10.1042/BSR20150014
ISSN: 1573-4935
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: © 2015 The Author(s)
Deposited On: 12 Oct 2016 02:36
Last Modified: 10 Apr 2017 05:07

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