Linking hypoxia and iron homeostasis: A ’plate' full of factors

Subramaniam, V. Nathan & Wallace, Daniel F. (2014) Linking hypoxia and iron homeostasis: A ’plate' full of factors. Gut, 63(12), pp. 1840-1842.

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Hepcidin, a 25-amino acid peptide expressed almost exclusively in the liver, is the central regulator of systemic body iron homeostasis. Since its initial identification and characterisation as an antimicrobial peptide, it has become clear that hepcidin plays a role in many metabolic processes. [...]it was shown to be increased in patients with oesophageal cancer 12 and patients with chronic pancreatitis. 13 In another study, it was shown to be decreased in patients with metabolic syndrome. 14 In cancer it could be postulated that in addition to enhancing angiogenesis, increased levels of PDGF-BB could benefit tumour growth via hepcidin suppression leading to both increased iron availability and increased red blood cell production and hence oxygen supply.

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ID Code: 99830
Item Type: Journal Article
Refereed: Yes
Keywords: Iron Metabolism
DOI: 10.1136/gutjnl-2014-306970
ISSN: 0017-5749
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2014 BMJ Publishing Group Limited
Deposited On: 13 Oct 2016 03:30
Last Modified: 14 Oct 2016 04:54

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