Transthyretin-thyroid hormone internalization by trophoblasts

Landers, K.A., Li, H., Subramaniam, V.N., Mortimer, R.H., & Richard, K. (2013) Transthyretin-thyroid hormone internalization by trophoblasts. Placenta, 34(8), pp. 716-718.

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Abstract

Normal fetal neurological development depends on a regulated supply of maternal thyroid hormone (TH). We have previously demonstrated that transthyretin (TTR) a TH binding protein, is synthesized, secreted and internalized by trophoblast cells and may provide a route for the transfer of TH from mother to fetus. Our objective was to determine if a member of the low-density lipoprotein receptor family mediates TTR or TTR-TH internalization.

TTR-TH internalization by JEG-3 cells is reduced in the presence of receptor associated protein (RAP) or albumin suggesting that TTR-TH is internalized through an LDL-receptor dependent endocytic process.

Impact and interest:

5 citations in Scopus
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4 citations in Web of Science®

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ID Code: 99836
Item Type: Journal Article
Refereed: Yes
Keywords: Thyroid hormone; Transthyretin; Endocytosis
DOI: 10.1016/j.placenta.2013.05.005
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Deposited On: 14 Oct 2016 00:38
Last Modified: 17 Oct 2016 02:55

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