Optimization of allogeneic mesenchymal progenitor cells for posterolateral spinal fusion with posterior instrumentation in sheep

Mulaibrahimovic, Adnan and Oakley, Andrew P. and Tizzard, Simon P. and LaRue, Bernard and Nikoloff, Steven and de Visser, Hans and Adam, Clayton J. and Pearcy, Mark J. and Vernon-Roberts, Barrie and Fraser, Robert D. and Moore, Robert J. (2007) Optimization of allogeneic mesenchymal progenitor cells for posterolateral spinal fusion with posterior instrumentation in sheep. In Proceedings The Adelaide Centre for Spinal Research - Spinal Research Symposium V, Adelaide, Australia.

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Abstract

Autologous bone is a finite resource and harvesting is associated with significant morbidity. This study investigated the safety and efficacy of allogeneic mesenchymal progenitor cells (MPCs) delivered via a calcium phosphate carrier to stimulate bone growth in spinal fusion compared to autograft control in an ovine model. MPCs promote early development of spinal fusion equivalent to autologous bone graft in this ovine model. Given the potential for significant clinical problems with autologous grafting consideration must be given to using MPCs in this setting.

Item Type:	Conference Paper
Status:	Published
Keywords:	mesenchymal progenitor cells, posterior instrumentation, spinal fusion, autograft, autologous bone
Subjects:	290000 Engineering and Technology > 291500 Biomedical Engineering > 291504 Biomechanical Engineering
ID Code:	13857
Deposited By:	Izatt, Maree T
Deposited On:	24 June 2008
Copyright Owner:	Copyright 2007 (please consult author)