Browse By Person: Richard, Derek
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Number of items: 32.
Jekimovs, Christian, Bolderson, Emma, Suraweera, Amila, Adams, Mark, O'Byrne, Kenneth J., & Richard, Derek J. (2014) Chemotherapeutic compounds targeting the DNA double-strand break repair pathways : the good, the bad, and the promising. Frontiers in Oncology, 4(86).
Bolderson, Emma, Petermann, Eva, Croft, Laura, Suraweera, Amila, Pandita, Raj K., Pandita, Tej K., et al. (2014) Human single-stranded DNA binding protein 1 (hSSB1/NABP2) is required for the stability and repair of stalled replication forks. Nucleic Acids Research, 42(10), pp. 6326-6336.
Gray, S.G., Barr, M.P., Fennell, D.A., O'Leary, J.J., Richard, Derek J., Thomale, J., et al. (2013) 2 MicroRNA profiling and cisplatin--DNA interactions in an isogenic model of cisplatin resistant NSCLC cell lines. Lung Cancer, 79(Supp1), S1.
Kavanagh, J.N., Currell, F.J., Timson, D.J., Savage, K.I., Richard, D.J., McMahon, S.J., et al. (2013) Antiproton induced DNA damage : proton like in flight, carbon-ion light near rest. Scientific Reports, 3(1770).
Barr, M. P, Gray , Steven G., O' Flaherty, John D, Fennell, Dean, O'Leary, JJ, O'Byrne, Kenneth J., et al. (2013) Generation and characterisation of Cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature. PLoS ONE, 8(1).
Jenkins, Glenn, O'Byrne, Kenneth J., Panizza, Benedict, & Richard, Derek J. (2013) Genome stability pathways in head and neck cancers. International Journal of Genomics, 2013(464720).
Ashton, Nicholas W., Bolderson, Emma, Cubeddu, Liza, O’Byrne, Kenneth J., & Richard, Derek J. (2013) Human single-stranded DNA binding proteins are essential for maintaining genomic stability. BMC Molecular Biology, 14(9).
O’Flaherty, John D., Barr, Martin, Fennell, Dean, Richard, Derek, Reynolds, John, O’Leary, John, et al. (2012) The cancer stem-cell hypothesis : its emerging role in lung cancer biology and its relevance for future therapy. Journal of Thoracic Oncology, 7(12), pp. 1880-1890.
Bolderson, Emma, Savage, K. I., Mahen, R., Pisupati, V., Graham, M. E., Richard, Derek J., et al. (2012) Krüppel-associated box (KRAB)-associated co-repressor (KAP-1) Ser-473 phosphorylation regulates heterochromatin protein 1 (HP1- ) mobilization and DNA repair in heterochromatin. Journal of Biological Chemistry, 287(33), pp. 28122-28131.
Cubeddu, Liza, Joseph, Soumya, Richard, Derek J., & Matthews, Jacqueline M. (2012) Contribution of DEAF1 structural domains to the interaction with the breast cancer oncogene LMO4. PLoS ONE, 7(6), e39218.
Busacca, Sara, Sheaff, Michael, Arthur, Kenneth, Gray, Steven G, O'Byrne, Kenneth J., Richard, Derek J., et al. (2012) BRCA1 is an essential mediator of vinorelbine-induced apoptosis in mesothelioma. The Journal of Pathology, 227(2), pp. 200-208.
Morris, Christelle, Tomimatsu, Nozomi, Richard, Derek J., Cluet, David, Burma, Sandeep, Khanna, Kum Kum, et al. (2012) INT6/EIF3E interacts with ATM and is required for proper execution of the DNA damage response in human cells. Cancer Research, 72(8), pp. 2006-2016.
O’Flaherty, John D., Gray, Steven, Richard, Derek, Fennell, Dean, O’Leary, John J., Blackhall, Fiona H., et al. (2012) Circulating tumour cells, their role in metastasis and their clinical utility in lung cancer. Lung Cancer, 76(1), pp. 19-25.
Paul, Ian, Savage, Kienan I, Blayney, Jaine K, Lamers, Elisabeth, Gately, Kathy, Kerr, Keith, et al. (2011) PARP inhibition induces BAX/BAK-independent synthetic lethality of BRCA1-deficient non-small cell lung cancer. Journal of Pathology, 224(4), pp. 564-574.
Wykes, Michele, Richard, Derek J., Kay, Jason G., Manderson, Anthony, Liu, Xue Q., Brown, Darren L., et al. (2011) Rodent blood-stage Plasmodium survive in dendritic cells that infect naive mice. Proceedings of the National Academy of Sciences, 108(27), pp. 11205-11210.
Urquhart, Aaron J., Gatei, Magtouf, Richard, Derek J., & Khanna, Kum Kum (2011) ATM mediated phosphorylation of CHD4 contributes to genome maintenance. Genome Integrity, 2(1), pp. 1-12.
Schettino, G., Ghita, M., Richard, D. J., & Prise, K. M. (2011) Spatiotemporal investigations of DNA damage repair using microbeams. Radiation Protection Dosimetry, 143(2-4), p. 340.
Richard, Derek J., Cubeddu, Liza, Urquhart, Aaron J., Bain, Amanda, Bolderson, Emma, Menon, Dinoop, et al. (2011) hSSB1 interacts directly with the MRN complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Research.
Bolderson, Emma, Tomimatsu, Nozomi, Richard, Derek J., Boucher, Didier, Kumar, Rakesh, Pandita, Tej K., et al. (2010) Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Research, 38(6), p. 1821.
Richard, Derek J., Savage, Kienan, Bolderson, Emma, Cubeddu, Liza, So, Sairei, Ghita, Mihaela, et al. (2010) hSSB1 rapidly binds at the sites of DNA double-strand breaks and is required for the efficient recruitment of the MRN complex. Nucleic Acids Research.
Skaar, Jeffrey R., Richard, Derek J., Saraf, Anita, Toschi, Alfredo, Bolderson, Emma, Florens, Laurence, et al. (2009) INTS3 controls the hSSB1-mediated DNA damage response. The Journal of Cell Biology, 187(1), pp. 25-32.
Bolderson, Emma, Richard, Derek J., Edelmann, Winfried, & Khanna, Kum Kum (2009) Involvement of Exo1b in DNA damage-induced apoptosis. Nucleic Acids Research, 37(10), pp. 3452-3463.
Richard, Derek, Bolderson, Emma, & Khanna, Kum Kum (2009) Multiple human single-stranded DNA binding proteins function in genome maintenance : structural, biochemical and functional analysis. Critical Reviews in Biochemistry and Molecular Biology, 44(2-3), pp. 98-116.
Bolderson, Emma, Richard, Derek J., Zhou, Bin-Bing S., & Khanna, Kum Kum (2009) Recent advances in cancer therapy targeting proteins involved in DNA double-strand break repair. Clinical Cancer Research, 15(20), pp. 6314-6320.
Li, Yongjian, Bolderson, Emma, Kumar, Rakesh, Muniandy, Parameswary, Xue, Yutong, Richard, Derek, et al. (2009) hSSB1 and hSSB2 form similar multiprotein complexes that participate in DNA damage response. Journal of Biological Chemistry, 284(35), pp. 23525-23531.
Richard, Derek J., Bolderson, Emma, Cubeddu, Liza, Wadsworth, Ross I. M., Savage, Kienan, Sharma, Girdhar G., et al. (2008) Single-stranded DNA-binding protein hSSB1 is critical for genomic stability. Nature, 453(7195), pp. 677-681.
Pagan, Julia K., Arnold, Jeremy, Hanchard, Kim J., Kumar, Raman, Bruno, Tiziana, Jones, Mathew J. K., et al. (2007) A novel corepressor, BCoR-L1, represses transcription through an interaction with CtBP. Journal of Biological Chemistry, 282(20), pp. 15248-15257.
Ariza, Antonio, Richard, Derek J., White, Malcolm F., & Bond, Charles S. (2005) Conformational flexibility revealed by the crystal structure of a crenarchaeal RadA. Nucleic Acids Research, 33(5), p. 1465.
Jekimovs, C.R., Chen, X., Arnold, J., Gatei, M., Richard, D.J., Spurdle, A.B., et al. (2005) Low frequency of CHEK2 1100delC allele in Australian multiple-case breast cancer families : functional analysis in heterozygous individuals. British Journal of Cancer, 92(4), pp. 784-790.
Richard, D. J. (2004) Physical and functional interaction of the archaeal single-stranded DNA-binding protein SSB with RNA polymerase. Nucleic Acids Research, 32(3), p. 1065.
Middleton, Claire L., Parker, Joanne L., Richard, Derek J., White, Malcolm F., & Bond, Charles S. (2004) Substrate recognition and catalysis by the Holliday junction resolving enzyme Hje. Nucleic Acids Research, 32(18), pp. 5442-5451.
Richard, Derek J., Schumacher, Vale´ rie, Royer-Pokora, Brigitte, & Roberts, Stefan G.E. (2001) Par4 is a coactivator for a splice isoform-specific transcriptional activation domain in WT1. Genes and Development, 15(3), pp. 328-339.