The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer

Jeffery, Penelope L., Herington, Adrian C., & Chopin, Lisa K. (2003) The potential autocrine/paracrine roles of ghrelin and its receptor in hormone-dependent cancer. Cytokine & Growth Factor Reviews, 14(2), pp. 113-122.

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Ghrelin is a recently identified 28 amino acid peptide capable of stimulating pituitary growth hormone release in humans. The actions of ghrelin are mediated via the naturally occurring ghrelin receptor, also known as the growth hormone secretagogue receptor (GHS-R). Ghrelin and its receptors are now being recognized as components of the growth hormone axis and are therefore potentially involved in tissue growth and development. As is the case for other members of this axis, evidence is rapidly emerging to indicate that ghrelin/GHS-R may play an important autocrine/paracrine role in some cancers. This review highlights the evidence for the expression, regulation and potential functional role of ghrelin and its receptor in hormone-dependent cancers, such as prostate and breast cancer.

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84 citations in Scopus
75 citations in Web of Science®
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ID Code: 10064
Item Type: Journal Article
Refereed: Yes
Additional Information: For more information, please refer to the journal’s website (see hypertext link) or contact the author.
Keywords: Ghrelin, Growth hormone secretagogues (GHSs), Growth hormone secretagogue receptor (GHS, R), Growth hormone (GH), Insulin, like growth factors (IGFs)
DOI: 10.1016/S1359-6101(02)00089-8
ISSN: 1359-6101
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2003 Elsevier
Deposited On: 10 Oct 2007 00:00
Last Modified: 29 Feb 2012 13:01

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