Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine
Sutherland, Heidi, Champion, Morgane, Plays, Amelie, Stuart, Shani, Haupt, Larisa, Frith, Alison, MacGregor, E. Anne, & Griffiths, Lyn (2017) Investigation of polymorphisms in genes involved in estrogen metabolism in menstrual migraine. Gene, 607, pp. 36-40.
|
Accepted Version
(PDF 508kB)
102916.pdf. Available under License Creative Commons Attribution Non-commercial No Derivatives 2.5. |
Description
Highlights • Polymorphisms in estrogen metabolism genes were investigated in menstrual migraine. • Polymorphisms were genotyped in a specific menstrual migraine case-control cohort. • COMT Val158Met, CYP1A1 Ile462Val and 3798T > C, and CYP19A1 Cys264Arg were studied. • None of the polymorphisms were significantly associated with menstrual migraine. Abstract Migraine is a common, disabling headache disorder, which is influenced by multiple genes and environmental triggers. After puberty, the prevalence of migraine in women is three times higher than in men and > 50% of females suffering from migraine report a menstrual association, suggesting hormonal fluctuations can influence the risk of migraine attacks. It has been hypothesized that the drop in estrogen during menses is an important trigger for menstrual migraine. Catechol-O-methyltransferase (COMT) and Cytochrome P450 (CYP) enzymes are involved in estrogen synthesis and metabolism. Functional polymorphisms in these genes can influence estrogen levels and therefore may be associated with risk of menstrual migraine. In this study we investigated four single nucleotide polymorphisms in three genes involved in estrogen metabolism that have been reported to impact enzyme levels or function, in a specific menstrual migraine cohort. 268 menstrual migraine cases and 142 controls were genotyped for rs4680 in COMT (Val158Met), rs4646903 and rs1048943 in CYP1A1 (T3801C and Ile462Val) and rs700519 in CYP19A1 (Cys264Arg). Neither genotype nor allele frequencies for the COMT and CYP SNPs genotyped were found to be significantly different between menstrual migraineurs and controls by chi-square analysis (P > 0.05). Therefore we did not find association of functional polymorphisms in the estrogen metabolism genes COMT, CYP1A1 or CYP19A1 with menstrual migraine. Further studies are required to assess whether menstrual migraine is genetically distinct from the common migraine subtypes and identify genes that influence risk.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
Full-text downloads:
Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
| ID Code: | 102916 | ||||||
|---|---|---|---|---|---|---|---|
| Item Type: | Contribution to Journal (Journal Article) | ||||||
| Refereed: | Yes | ||||||
| ORCID iD: |
|
||||||
| Measurements or Duration: | 5 pages | ||||||
| DOI: | 10.1016/j.gene.2017.01.008 | ||||||
| ISSN: | 0378-1119 | ||||||
| Pure ID: | 33198784 | ||||||
| Divisions: | Past > Institutes > Institute of Health and Biomedical Innovation | ||||||
| Copyright Owner: | Consult author(s) regarding copyright matters | ||||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
| Deposited On: | 19 Jan 2017 14:21 | ||||||
| Last Modified: | 20 Apr 2026 19:46 |
Export: EndNote | Dublin Core | BibTeX
Repository Staff Only: item control page