Regulation of human neural stem cell fate determination by proteoglycans
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Description
This thesis investigated how human neural stem cells are regulated, focusing specifically on heparan sulfate proteoglycans, the key proteins of the extracellular space. The findings of this study identified central roles for proteoglycans in mediating neural stem cell events, including self-renewal and differentiation. This research has improved our understanding of human stem cell and human neurogenesis biology and provided novel approaches for the development of improved neural stem cell applications, including using these cells for brain damage therapy.
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| ID Code: | 103844 |
|---|---|
| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Haupt, Larisa M. & Griffiths, Lyn R. |
| Keywords: | Neural stem cell, Heparan sulfate proteoglycan, Neurogenesis, Neuron, Astrocyte, Syndecan, Glypican, Extracellular matrix |
| DOI: | 10.5204/thesis.eprints.103844 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 24 May 2017 01:58 |
| Last Modified: | 12 Sep 2017 14:42 |
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