Serotonin and noradrenaline signalling in binge-like long-term alcohol intake and associated maladaptive effects in adult mice
Description
Alcohol dependence is a debilitating disorder with current therapies displaying limited efficacy and/or compliance. This thesis investigated the contribution of two key neurotransmitters; noradrenaline and serotonin in alcohol dependence using a mouse model of binge-like alcohol consumption. Using this model, the study demonstrated that long-term alcohol intake causes neuroadaptive changes in the signalling of these molecules leading to alterations in normal emotional states and alcohol dependence. Finally, the thesis highlighted the efficacy of the FDA approved drug for hypertension pindolol and the anxiolytic drug tandospirone to reduce alcohol consumption, thereby offering a novel approach to improve treatments for alcohol addiction.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
Full-text downloads:
Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
ID Code: | 103955 |
---|---|
Item Type: | QUT Thesis (PhD by Publication) |
Supervisor: | Bartlett, Selena & Pollock, Pamela |
Keywords: | long-term, binge-like, alcohol, noradrenaline, serotonin, pindolol, tandospirone, synaptic triads |
DOI: | 10.5204/thesis.eprints.103955 |
Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Clinical Sciences |
Institution: | Queensland University of Technology |
Deposited On: | 10 Jul 2017 05:09 |
Last Modified: | 01 Apr 2018 14:00 |
Export: EndNote | Dublin Core | BibTeX
Repository Staff Only: item control page