Investigating the role of the epithelial-mesenchymal plasticity in prostate cancer
Description
This thesis was a step forward in better understanding the involvement of cancer cell plasticity in the progression of prostate cancer to aggressive disease. These studies described for the first time the transcriptional landscape of epithelial-mesenchymal plasticity in prostate cancer which led to the discovery of a molecular signature capable of identifying high-risk patients. In addition, this project revealed new-found molecular targets that may regulate cancer cell plasticity, thus making them attractive therapeutic options for patients with prostate cancer.
Impact and interest:
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ID Code: | 107979 |
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Item Type: | QUT Thesis (PhD) |
Supervisor: | Hollier, Brett, Nelson, Colleen, & Gunter, Jennifer |
Keywords: | Epithelial mesenchymal transition, EMT, Mesenchymal epithelial transition, MET, Prostate cancer, Plasticity, metastasis, survival, recurrence, invasion |
DOI: | 10.5204/thesis.eprints.107979 |
Institution: | Queensland University of Technology |
Deposited On: | 16 Nov 2017 04:50 |
Last Modified: | 18 Sep 2020 02:04 |
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