Functional analysis of prostate cancer-associated germline variants in the kallikrein-3 gene
![[img]](https://eprints.qut.edu.au/secure/style/images/fileicons/application_pdf.png)
Description
This thesis is a comprehensive analysis of two functional germline variants of prostate specific antigen (PSA), the current widely used biomarker for prostate cancer diagnosis. It examines the mechanisms through which the two germline variants play a role in prostate cancer pathogenesis. Additionally, the clinical impact of these two variants in mediating the detection of the PSA protein in serum of men was analysed. This project is a step forward in utilising these germline variants, that lead to changes to the PSA protein, to personalise the current approach for prostate cancer diagnostics.
Impact and interest:
Citation counts are sourced monthly from Scopus and Web of Science® citation databases.
These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.
Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.
Full-text downloads:
Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.
| ID Code: | 108027 |
|---|---|
| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Clements, Judith & Batra, Jyotsna |
| Keywords: | Prostate specific antigen (PSA), Single nucleotide polymorphisms, Prostate cancer, Genome wide association studies, Diagnostic marker, Kallikrein-related peptidase, Splice variants, Enzyme activity, Protein stability |
| DOI: | 10.5204/thesis.eprints.108027 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 06 Oct 2017 04:03 |
| Last Modified: | 15 Jun 2019 14:00 |
Export: EndNote | Dublin Core | BibTeX
Repository Staff Only: item control page