Examining the Influence of Biological and Psychological Factors on Cognitive Performance in Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study

Smith, Simon & Sullivan, Karen A. (2003) Examining the Influence of Biological and Psychological Factors on Cognitive Performance in Chronic Fatigue Syndrome: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study. International Journal of Behavioral Medicine, 10(2), pp. 162-173.

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The pathophysiology of chronic fatigue syndrome (CFS) remains unclear; however, both biological and psychological factors have been implicated in establishing or maintaining this condition. People with CFS report significant and disabling cognitive difficulties such as impaired concentration that in some cases are exacerbated by exposure to chemical triggers. The aim of this study was to determine if neuropsychological deficits in CFS are triggered by exposure to chemicals, or perceptions about the properties of these substances. Participants were 36 people with a primary diagnosis of CFS, defined according to Centers for Disease Control (CDC) criteria. A randomized, double-blind, placebo-controlled, crossover design was used, with objective assessment of neuropsychological function and participant rating of substance type, before and after exposure to placebo or chemical trigger. Results showed decrements in neuropsychological tests scores on three out of four outcome measures when participants rated the substance they had been exposed to as "chemical." No change in performance was found based on actual substance type. These results suggest that cognitive attributions about exposure substances in people with CFS may be associated with worse performance on neuropsychological tasks. In addition, these findings suggest that psychological interventions aimed at modifying substance-related cognitions may reduce some symptoms of CFS.

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12 citations in Scopus
9 citations in Web of Science®
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ID Code: 109
Item Type: Journal Article
Refereed: Yes
Keywords: Chronic fatigue syndrome, Crossover trials, Neuropsychological tests
DOI: 10.1207/S15327558IJBM1002_05
ISSN: 1532-7558
Subjects: Australian and New Zealand Standard Research Classification > PSYCHOLOGY AND COGNITIVE SCIENCES (170000) > PSYCHOLOGY (170100) > Biological Psychology (Neuropsychology Psychopharmacology Physiological Psychology) (170101)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2003 Taylor & Francis
Copyright Statement: This is an electronic version of an article published in [International Journal of Behavioral Medicine 10(2):pp. 162-173.].
Deposited On: 18 Jun 2004 00:00
Last Modified: 29 Feb 2012 12:57

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