Midbrain dopamine and prefrontal function in humans: Interaction and modulation by COMT genotype
Description
Using multimodal neuroimaging in humans, we demonstrate specific interactions between prefrontal activity and midbrain dopaminergic synthesis. A common V(108/158)M substitution in the gene for catecholamine-O-methyltransferase (COMT), an important enzyme regulating prefrontal dopamine turnover, predicted reduced dopamine synthesis in midbrain and qualitatively affected the interaction with prefrontal cortex. These data implicate a dopaminergic tuning mechanism in prefrontal cortex and suggest a systems-level mechanism for cognitive and neuropsychiatric associations with COMT.
Impact and interest:
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| ID Code: | 110201 | ||
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| Item Type: | Contribution to Journal (Journal Article) | ||
| Refereed: | Yes | ||
| ORCID iD: |
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| Keywords: | Adult, Amino Acid Substitution/genetics, Brain Mapping, Catechol O-Methyltransferase/*genetics, Cognition/*physiology, Dopamine/*metabolism, Feedback/physiology, Female, Genotype, Humans, Male, Memory, Short-Term/physiology, Mesencephalon/diagnostic imaging/*enzymology, Metabolic Clearance Rate/physiology, Neural Pathways/diagnostic imaging/*enzymology, Neuropsychological Tests, Positron-Emission Tomography, Prefrontal Cortex/diagnostic imaging/*enzymology, Reaction Time/genetics, Synaptic Transmission/physiology | ||
| DOI: | 10.1038/nn1438 | ||
| ISSN: | 1546-1726 | ||
| Pure ID: | 60205736 | ||
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
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| Copyright Owner: | Copyright 2004 American Medical Association | ||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
| Deposited On: | 21 Aug 2017 23:34 | ||
| Last Modified: | 04 Aug 2024 13:20 |
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