Solving the pathogenesis of ankylosing spondylitis
Brown, Matt (2018) Solving the pathogenesis of ankylosing spondylitis. Clinical Immunology, 186, pp. 46-50.
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Description
• HLA-B associations of AS are complex, with protective and risk associations in addition to the associations with HLA-B27 having been established. • Interaction between ERAP1 and HLA-B27 and -B40 has been demonstrated, indicating that ERAP1 works probably by similar mechanisms, with these genes to cause AS. • AS appears to be driven by interaction between the gut microbiome and host immune system offering the potential to treat the condition by gut targeted therapies. • HLA-B27 forms homodimers, and there is strong evidence that these operate in AS to induce AS through interactions with KIR bearing immune cells.
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| ID Code: | 223109 | ||
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| Item Type: | Contribution to Journal (Journal Article) | ||
| Refereed: | Yes | ||
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| Measurements or Duration: | 5 pages | ||
| Keywords: | Aminopeptidase genes and AS, ERAP1, HLA-B associations, HLA-B27, HLA-B40, ankylosing spondylitis | ||
| DOI: | 10.1016/j.clim.2017.07.011 | ||
| ISSN: | 1521-6616 | ||
| Pure ID: | 33324173 | ||
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation |
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| Copyright Owner: | Consult author(s) regarding copyright matters | ||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||
| Deposited On: | 07 Nov 2021 03:37 | ||
| Last Modified: | 01 Nov 2025 18:47 |
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