Cardiolipin effects on the gating behaviour and reconstitution of MscL and MscS
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Description
The mechanosensitive channels of large (MscL) and small (MscS) conductance act as osmosensors in bacterial cells against hypo-osmotic shock. MscL has been extensively studied by reconstitution into liposomes, however MscS has proved more difficult to reconstitute, requiring high protein-lipid ratios. We recently published an improved reconstitution method for both MscL and MscS in soy azolectin, a mixture that contains lipids, sugars and sterols. We have expanded these results and show here the effect of both individual and mixtures of lipids on the reconstitution and channel gating behaviour of co-reconstituted MscL and MscS.
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| ID Code: | 114037 |
|---|---|
| Item Type: | Contribution to conference (Poster) |
| Refereed: | Yes |
| Pure ID: | 57306976 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Copyright Owner: | 2011 Biophysical Society |
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| Deposited On: | 29 Nov 2017 00:40 |
| Last Modified: | 01 Mar 2024 23:08 |
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