Modulation of the G22E MscL mutant channel gating by Lipid Bilayer constituents and gadolinium
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Description
Bacteria respond to hypoosmotic changes through the mechanosensitive (MS) channels of Large (MscL) and Small (MscS) conductance, MscS responds first to pressure, i.e. bilayer tension changes, followed by MscL. The lipid environment, lyso lipids and cholesterol have been shown to significantly influence the ratio of the opening of MscL to MscS. Furthermore, introduction of the highly negatively charged cardiolipin to both azolectin and POPE/POPC lipid membranes causes rapid gating of MscS. Here we report an expanded study using the spontaneously active G22E MscL mutant which, although spontaneously active, is still mechanosensitive.
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| ID Code: | 114051 |
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| Item Type: | Contribution to conference (Poster) |
| Refereed: | Yes |
| Pure ID: | 57305777 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation |
| Copyright Owner: | 2013 Biophysical Society |
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| Deposited On: | 29 Nov 2017 00:11 |
| Last Modified: | 01 Mar 2024 23:07 |
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