Utilization of a novel 3D culture technology for the assessment of chemo-resistance in non-small cell lung cancer: Topic: biomarkers (Conference Abstract)
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Utilization of a Novel 3D Culture Technology for the Assessment of Chemo-Resistance in Non-Small Cell Lung Cancer.pdf. Administrators only | Request a copy from author |
Description
Elucidation of the key mechanisms underlying resistance to chemotherapy is an on-going and complex process. Owing to its suggested increased biological relevance, many are now transitioning from two-dimensional (2D) to three-dimensional (3D) cellular-based assay systems. These systems permit the formation of 3D multicellular structures (MCS). The internal micro-environment of these structures mimics closely those found in vivo. In addition they are considered to provide a more biologically relevant model of chemo-resistance. This study focuses on the utilization of a novel 3D culture technology to compare chemo-resistant models of non-small cell lung cancer (NSCLC) in 3D culture with those cultured in 2D monolayers. Critically, this will provide a valuable tool to determine the biological discrepancies which exist between the two culture methods with the aim to identify novel mechanisms of chemo-resistance in NSCLC.
Impact and interest:
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| ID Code: | 118034 | ||||||
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| Item Type: | Contribution to Journal (Meeting Abstract) | ||||||
| Refereed: | No | ||||||
| ORCID iD: |
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| Additional Information: | Only abstract published | ||||||
| Measurements or Duration: | 2 pages | ||||||
| Keywords: | 3D culture technology, Assessment, Chemoresistance, NSCLC, non-small-cell lung cancer | ||||||
| DOI: | 10.1016/j.jtho.2016.11.1378 | ||||||
| ISSN: | 1556-0864 | ||||||
| Pure ID: | 34535480 | ||||||
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation |
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| Copyright Owner: | Consult author(s) regarding copyright matters | ||||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
| Deposited On: | 04 May 2018 04:47 | ||||||
| Last Modified: | 30 Apr 2024 20:36 |
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