CCL chemokines may play an important role in cisplatin resistance: Topic: proteins in lung cancer and proteomics (Conference Abstract)

, Godwin, Peter, Heavey, Susan, Umezawa, Kazuo, Barr, Martin, Gray, Steven, Stanfill, Bryan, , Cuffe, Sinead, Finn, Stephen, , Gately, Kathy, , & (2017) CCL chemokines may play an important role in cisplatin resistance: Topic: proteins in lung cancer and proteomics (Conference Abstract). Journal of Thoracic Oncology, 12(1(S)), S803-S804.

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Description

In the absence of a targetable mutation, cisplatin based chemotherapy is the backbone of NSCLC treatment. However, a diverse patient population combined with complex tumor heterogeneity is hampering its’ clinical utility. Although intrinsic and acquired resistance to cisplatin is common, the mechanisms have not yet been fully elucidated. However, some studies have suggested that inflammatory pathways may play a key role in chemo-resistance. The aim of this project is to increase our understanding of inflammatory mediated cisplatin resistance in NSCLC.

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ID Code: 118043
Item Type: Contribution to Journal (Meeting Abstract)
Refereed: No
ORCID iD:
Ryan, Sarah-Louiseorcid.org/0000-0002-7307-5500
Richard, Derekorcid.org/0000-0002-4839-8471
O'Byrne, Kenorcid.org/0000-0002-6754-5633
Additional Information: Only abstract published
Measurements or Duration: 2 pages
Keywords: CCL chemokines, NSCLC, cisplatin, cisplatin resistance, non-small-cell lung cancer
DOI: 10.1016/j.jtho.2016.11.1083
ISSN: 1556-0864
Pure ID: 34534565
Divisions: Past > QUT Faculties & Divisions > Faculty of Health
Past > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Consult author(s) regarding copyright matters
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Deposited On: 04 May 2018 04:42
Last Modified: 30 Apr 2024 20:14