Investigating the role of neuronal nicotinic acetylcholine receptor subtypes in the acquisition and maintenance of alcohol use disorders
Description
Owing to the substantial comorbidity of nicotine and alcohol, this project was designed to explore the role that neuronal nicotinic acetylcholine receptors play in the development of alcohol use disorders. This study utilised well-established animal models, documenting the impact of 'binge-like' ethanol consumption on the expression of these receptors in key brain areas governing stress and reward. Only by continuing to uncover the neurological changes attributed to alcohol consumption, can we further elucidate treatment options for those affected.
Impact and interest:
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| ID Code: | 118142 |
|---|---|
| Item Type: | QUT Thesis (PhD by Publication) |
| Supervisor: | Bartlett, Selena & Pollock, Pamela |
| Additional Information: | The Faculty has granted an embargo until 5th April 2019. |
| Keywords: | alcohol, nAChR, CHRNA4, nucleus accumbens, amygdala, varenicline, addiction, pre-frontal cortex, early life stress, nicotine |
| DOI: | 10.5204/thesis.eprints.118142 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Clinical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 12 Jun 2018 05:18 |
| Last Modified: | 05 Apr 2019 14:00 |
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