Current understanding of DNA methylation and age-related disease
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Description
DNA methylation involves the covalent transfer of a methyl group to the C-5 position of the cytosine ring on a DNA strand. DNA methylation is both heritable and modifiable and can affect gene expression. In recent years, epigenome-wide association studies using high-throughput technologies have associated variation in DNA methylation levels with normal and pathological aging processes in human populations. DNA methylation patterns have been used to construct epigenetic clocks which can serve as potential biomarkers of age-related diseases. Age acceleration, as determined using these epigenetic clocks, has been strongly linked to common diseases including cancer, neurodegenerative diseases, metabolic diseases, and cardiovascular diseases. Identification of these robust associations between DNA methylation and aging may provide new potential therapeutic avenues for preventing and treating age-related diseases. This review focuses on the role of DNA methylation in aging processes and recent advances in epigenome-wide association studies (EWASs) reporting associations between DNA methylation and age-related diseases.
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| ID Code: | 120130 | ||||||||
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| Item Type: | Contribution to Journal (Journal Article) | ||||||||
| Refereed: | Yes | ||||||||
| ORCID iD: |
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| Measurements or Duration: | 17 pages | ||||||||
| Keywords: | Aging, DNA methylation, Diseases, EWAS, Epigenetic therapies, Epigenetics | ||||||||
| DOI: | 10.21926/obm.genet.1802016 | ||||||||
| ISSN: | 2577-5790 | ||||||||
| Pure ID: | 33365071 | ||||||||
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
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| Copyright Owner: | Consult author(s) regarding copyright matters | ||||||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||||
| Deposited On: | 24 Jul 2018 04:48 | ||||||||
| Last Modified: | 28 Jun 2024 14:18 |
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