The role of the equine enteroinsular axis in insulin dysregulation: In vitro mechanistic insights for disease prevention
Kheder, Murad Hasan (2018) The role of the equine enteroinsular axis in insulin dysregulation: In vitro mechanistic insights for disease prevention. PhD thesis, Queensland University of Technology.
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Murad Kheder Thesis (PDF 8MB) |
Description
Insulin dysregulation encompasses abnormalities in insulin metabolism, including hyperinsulinaemia and insulin resistance. These abnormalities cause diseases in horses and humans, including laminitis and type-2 diabetes mellitus, respectively. This project investigated the role of incretins, and their receptors, in equine insulin dysregulation, and also examined the inhibitory effect of sweet-taste receptor antagonists on intestinal glucose uptake. The project discovered that incretin action and glucose uptake can be attenuated in horses using incretin, and sweet-taste receptor, antagonists, respectively. This is a novel approach to reducing hyperinsulinaemia. Thus, these pathways should be further investigated as novel therapies for metabolic syndrome and laminitis.
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| ID Code: | 122879 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | de Laat, Melody & Sillence, Martin |
| Keywords: | Incretins, Hyperinsulinaemia, Insulin resistance, Glucagon-like peptide-1, Glucose-dependent insulinotropic polypeptide, Metabolic syndrome, cardiovascular disease, Sweet-taste receptors, Glucose uptake, Insulin positive feedback |
| DOI: | 10.5204/thesis.eprints.122879 |
| Divisions: | Past > QUT Faculties & Divisions > Science & Engineering Faculty Past > Schools > School of Earth, Environmental & Biological Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 29 Nov 2018 10:05 |
| Last Modified: | 23 Jan 2025 00:45 |
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