Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis (Letter)

Cortes, Adrian, Gladman, Dafna, Raychaudhuri, Soumya, Cui, Jing, , & (2018) Imputation-based analysis of MICA alleles in the susceptibility to ankylosing spondylitis (Letter). Annals of the Rheumatic Diseases, 77(11), pp. 1691-1692.

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Ankylosing spondylitis (AS) susceptibility is strongly correlated with genetic variation within the major histocompatibility complex (MHC), and the class I HLA-B27 allele confers the major genetic risk factor to AS. Furthermore, strong evidence for additional alleles in the MHC has been observed which affect susceptibility independently from the HLA-B27 allele, either by direct genotyping in candidate gene studies or through large-scale imputation-driven association studies. We have previously identified variants in both class I and II which affect susceptibility to AS through imputation of classical HLA alleles...

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15 citations in Scopus
14 citations in Web of Science®
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ID Code: 124020
Item Type: Contribution to Journal (Letter)
Refereed: No
ORCID iD:
Brown, Mattorcid.org/0000-0003-0538-8211
Additional Information: Letter - 2 pages
Measurements or Duration: 2 pages
Keywords: ankylosing spondylitis, gene polymorphism, inflammation
DOI: 10.1136/annrheumdis-2018-213413
ISSN: 1468-2060
Pure ID: 34537084
Divisions: Past > QUT Faculties & Divisions > Faculty of Health
Past > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Consult author(s) regarding copyright matters
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Deposited On: 07 Jan 2019 10:52
Last Modified: 10 Nov 2025 07:10