Diversity of arthropod-borne viruses and implications for Wolbachia-based biocontrol
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O'mezie Ekwudu Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
This research examines the impact of genetic diversity in dengue virus (DENV) on incubation period in vector mosquitoes, and on Wolbachia, a novel vector biocontrol agent. It also extends the DENV study to other flaviviruses (Zika and West Nile - Kunjin) and alphaviruses (Barmah Forest, Ross River and Sindbis) to provide evidence as to whether a heat-resistant strain of Wolbachia, wAlbB, can be used to suppress the transmission of these mosquito-borne viruses. The research outcomes show that viral genetic variation is reflected in transmission kinetics of DENV. Data from the Wolbachia experiments provide the groundwork for future in vivo mosquito trials.
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| ID Code: | 127159 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Frentiu, Francesca, Huygens, Flavia, Aaskov, John, & Devine, Gregor |
| Keywords: | Arthropod-borne viruses, Arboviruses, Dengue virus, Aedes aegypti, Aedes albopictus, Wolbachia, Extrinsic incubation period, Genetic diversity, Vector mosquito, Zika virus |
| DOI: | 10.5204/thesis.eprints.127159 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 17 Dec 2021 05:02 |
| Last Modified: | 17 Dec 2021 05:02 |
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