Genetic variation of the HFE gene and associated proteomes in chronic venous leg ulceration
Sydes, Elizabeth R. (2019) Genetic variation of the HFE gene and associated proteomes in chronic venous leg ulceration. Master of Philosophy thesis, Queensland University of Technology.
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Elizabeth Sydes Thesis
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Description
This project was conducted to determine whether the genetic variance of an iron regulatory gene was associated with the development or severity of chronic venous leg ulceration. In addition, the study examined the association of wound exudate protein composition with both the genetic variance of the target gene and wound healing outcomes. The evidence collected supported the hypothesis that wound healing may be affected by dysregulation of iron. By virtue of the discovery phase protein profiling methods used, a wound fluid protein reference library was created, against which future studies may be searched to identify potential therapeutic targets.
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| ID Code: | 127835 |
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| Item Type: | QUT Thesis (Master of Philosophy) |
| Supervisor: | Parker, Tony, Parker, Christina, Wallace, Daniel, Maresco-Pennisi, Diane, & Broszczak, Daniel |
| Keywords: | Chronic venous disease, Chronic wounds, Data independent acquisition, Gene Ontology, Genetic variation, Hereditary Haemochromatosis, HFE, Iron Overload, Proteomics, SWATH-MS |
| DOI: | 10.5204/thesis.eprints.127835 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 09 Apr 2019 06:54 |
| Last Modified: | 22 Jan 2025 14:45 |
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