Deciphering the role of the protein phosphatase EYA4 in preventing genomic instability and breast cancer development
De La Pena Avalos, Barbara L. (2019) Deciphering the role of the protein phosphatase EYA4 in preventing genomic instability and breast cancer development. PhD thesis, Queensland University of Technology.
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Barbara De La Pena Avalos Thesis
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Description
This research used a multidisciplinary approach to decipher the function of the atypical protein phosphatase EYA4. By combining molecular and cell biology approaches and in vivo validation in mice, this project investigated the potential novel role of EYA4 in the maintenance of genomic integrity and its implication in breast cancer development. In doing so, EYA4 was identified as a potential novel breast cancer gene that is essential to maintain genomic stability and plays an important role in DNA damage repair. These findings open up new possibilities for cancer diagnostics and anticancer therapeutic approaches.
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| ID Code: | 129468 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Stephenson, Sally-Anne, Dray, Eloise, & Paquet, Nicolas |
| Keywords: | EYA4, breast cancer, genomic stability, DNA repair, DNA replication |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 17 Dec 2021 15:07 |
| Last Modified: | 24 Jan 2025 00:43 |
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