Delineating the role of Hepatocyte nuclear factor 1 beta (HNF1B) transcript variants in prostate cancer
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Shubhra Chandra Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
Genome Wide Association Studies (GWAS) has identified HNF1B located at chromosome 17q12 as foremost risk gene for prostate cancer susceptibility in multi-ethnic populations. This thesis characterises the HNF1B transcript variants along with defining their expression pattern and functional attributes in prostate cancer. Future research will enable the discovery of the molecular mechanism of their actions and whether targeting these HNF1B transcript variants in cancer may prove a useful therapeutic strategy.
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| ID Code: | 135713 |
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| Item Type: | QUT Thesis (Master of Philosophy) |
| Supervisor: | Batra, Jyotsna & Clements, Judith |
| Measurements or Duration: | 0 |
| Keywords: | Genome wide association studies (GWAS), Hepatocyte nuclear factor 1 beta (HNF1B), single nucleotide polymorphisms (SNPs), Prostate Cancer (PCa), Splice variants |
| DOI: | 10.5204/thesis.eprints.135713 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 21 Jan 2020 05:40 |
| Last Modified: | 09 Mar 2020 05:53 |
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