Modulation of Placental Gene Expression in Small-for-Gestational-Age Infants
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136740. Available under License Creative Commons Attribution 4.0. |
Description
Small-for-gestational-age (SGA) infants are fetuses that have not reached their genetically programmed growth potential. Low birth weight predisposes these infants to an increased risk of developing cardiovascular, metabolic and neurodevelopmental conditions in later life. However, our understanding of how this pathology occurs is currently incomplete. Previous research has focused on understanding the transcriptome, epigenome and bacterial signatures separately. However, we hypothesise that interactions between moderators of gene expression are critical to understanding fetal growth restriction. Through a review of the current literature, we identify that there is evidence of modulated expression/methylation of the placental genome and the presence of bacterial DNA in the placental tissue of SGA infants. We also identify that despite limited evidence of the interactions between the above results, there are promising suggestions of a relationship between bacterial signatures and placental function. This review aims to summarise the current literature concerning fetal growth from multiple avenues and propose a novel relationship between the placental transcriptome, methylome and bacterial signature that, if characterised, may be able to improve our current understanding of the placental response to stress and the aetiology of growth restriction.
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ID Code: | 136740 | ||||||
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Item Type: | Contribution to Journal (Review article) | ||||||
Refereed: | Yes | ||||||
ORCID iD: |
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Measurements or Duration: | 23 pages | ||||||
Keywords: | SGA, bacterial signatures, gene regulation, placenta | ||||||
DOI: | 10.3390/genes11010080 | ||||||
ISSN: | 2073-4425 | ||||||
Pure ID: | 43066436 | ||||||
Divisions: | Current > Research Centres > Centre for Agriculture and the Bioeconomy Current > Research Centres > Centre for Immunology and Infection Control Past > Institutes > Institute of Health and Biomedical Innovation Past > QUT Faculties & Divisions > Science & Engineering Faculty Current > QUT Faculties and Divisions > Faculty of Science Current > Schools > School of Biology & Environmental Science Current > QUT Faculties and Divisions > Faculty of Health |
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Copyright Owner: | The Author(s) | ||||||
Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
Deposited On: | 30 Jan 2020 01:01 | ||||||
Last Modified: | 02 Aug 2024 22:23 |
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