The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells

Hosokawa, Kazuyuki, Chen, Philip, Lavin, Martin, & Bottle, Steven E. (2004) The impact of carboxy nitroxide antioxidants on irradiated ataxia telangiectasia cells. Free Radical Biology and Medicine, 37(7), pp. 946-952.

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Abstract

Three water-soluble carboxy nitroxide antioxidants, 5-carboxy-1,1,3,3-tetramethylisoindolin-2-yloxyl, 4-carboxy-2,2,6,6-tetramethylpiperidin-1-yloxyl, and 3-carboxy-2,2,5,5-tetramethylpyrrolidin-1-yloxyl, show significant impact on the postirradiation survival rates of ataxia telangiectasia (A-T) cells compared to normal cells, an assay which represents a model for understanding the impact of ROS damage on the A-T phenotype. The effects of these antioxidants are much more significant than those of vitamin E or Trolox (a water-soluble vitamin E analog), studied using the same cell survival model

Impact and interest:

11 citations in Scopus
10 citations in Web of Science®
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525 since deposited on 11 Oct 2005
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ID Code: 1668
Item Type: Journal Article
Refereed: Yes
Keywords: Nitroxide, Ataxia telangiectasia, Antioxidant, ROS, Free radical, Oxidative stress
DOI: 10.1016/j.freeradbiomed.2004.06.035
ISSN: 0891-5849
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000)
Divisions: Past > QUT Faculties & Divisions > Faculty of Science and Technology
Copyright Owner: Copyright 2004 Elsevier
Copyright Statement: Reproduced in accordance with the copyright policy of the publisher.
Deposited On: 11 Oct 2005 00:00
Last Modified: 29 Feb 2012 13:09

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