Routine changing of intravascular administration sets does not reduce colonisation or infection in central venous catheters

Rickard, Claire, Lipman, Jeff, Courtney, Mary D., Siversen, Rosemary, & Daley, Peter (2004) Routine changing of intravascular administration sets does not reduce colonisation or infection in central venous catheters. Infection Control and Hospital Epidemiology, 25(8), pp. 650-655.


Objective: To determine the effect of routine intravascular administration-set changes on central venous catheter (CVC) colonization and catheter related bacteremia (CRB).

Design: Prospective, randomised controlled trial

Setting: 18-bed ICU in a University-affiliated, tertiary referral hospital.

Participants: 404 chlorhexidine and silver sulfadiazine coated multi-lumen CVCs from 251 intensive care unit (ICU) patients.

Interventions: After ethical approval, CVCs inserted in ICU and in situ on Day 4 were randomised to have their administration-sets changed on Day 4 (n = 203) or not at all (n = 201). Fluid container and blood product administration-set use was limited to 24 hours. CVCs were removed (Day 7, not required or suspected infection), and cultured for colonization ( 15 cfu). Medical and laboratory staff were blinded. CRB was diagnosed by a blinded intensivist using strict definitions. Data was collected on; catheter life, CVC site, APACHE II score, patient age, diagnosis, hyperglycemia, hypoalbuminemia, immune status, number of fluid containers and intravenous injections, propofol, blood, TPN or lipid infusion.

Results: There were 10 colonized CVCs in the set change group and 19 in the no change group. This was not a statistically significant difference on Kaplan Meier survival analysis (Effect Size = 0.09, Log Rank = 0.87, df = 1, p = 0.35). There were 3 cases of CRB per group. Logistic regression found that burns diagnosis and increased ICU stay were the only factors that significantly predicted colonization (p < 0.001).

Conclusions: Intravenous administration-sets can be used for 7-days. Routine administration-set changes are unnecessary before this time.

Impact and interest:

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ID Code: 1731
Item Type: Journal Article
Refereed: No
Additional URLs:
Keywords: Intravascular administration, set, catheter colonization, catheter related bacteremia, intensive care, central venous catheter
ISSN: 1559-6834
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > NURSING (111000) > Clinical Nursing - Secondary (Acute Care) (111003)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 The Society for Healthcare Epidemiology of America
Copyright Statement: Reproduced in accordance with the copyright policy of the publisher.
Deposited On: 01 Jul 2005 00:00
Last Modified: 29 Feb 2012 13:07

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