Expression, function, and regulation of two key genes involved in prostate cancer metabolism
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Sugarniya Subramaniam Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
Metabolic deregulation is an emergent hallmark of prostate cancer and studies show that altered patterns of metabolic pathways involved in the development of malignancy. A large genetic association on microRNA (miRNA) related genetic variations recently identified single nucleotide polymorphisms (SNPs) in two key metabolic genes. This thesis analysed the role of metabolic genes and functional validation of SNPs and associated miRNAs involved in the regulation of these genes as a mediator of prostate cancer aetiology. The findings from this study suggest that studies of miRNAs and their interactions with SNPs could provide valuable insights into the complicated mechanisms of prostate cancer risk and identify suitable molecular pathways for targeted therapy.
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| ID Code: | 200151 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Batra, Jyotsna, Jeet, Varinder, & Clements, Judith |
| Keywords: | Prostate cancer, pyruvate dehydrogenase kinase 1, malonyl-CoA-acyl carrier protein transacylase, microRNA, miRSNP, metabolism, glycolysis, lipogenesis, hypoxia, androgen |
| DOI: | 10.5204/thesis.eprints.200151 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 22 May 2020 07:01 |
| Last Modified: | 23 May 2021 14:00 |
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