Investigation of mice deficient in matriptase-2, Hfe and transferrin receptor 2 reveals a novel non-hepatic role for Tfr2 in erythropoiesis
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Description
The liver expressed proteins matriptase‐2 (MT‐2, encoded by TMPRSS6 ), HFE and Transferrin receptor 2 (TFR2) play important roles in systemic iron homeostasis by regulating the expression of the iron regulatory hormone hepcidin in the liver. Mutations in TMPRSS6 lead to iron refractory iron deficiency anaemia, whereas mutations in HFE and TFR2 lead to hereditary hemochromatosis. We generated mice lacking various combinations of Tmprss6 , Hfe and Tfr2 to further elucidate the potentially competing roles of these proteins in hepcidin regulation, iron homeostasis and erythropoiesis.
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| ID Code: | 200520 | ||||||
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| Item Type: | Contribution to Journal (Meeting Abstract) | ||||||
| Refereed: | No | ||||||
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| Additional Information: | Special Issue: Australian Gastroenterology Week 2014 Gold Coast Convention & Exhibition Centre, Broadbeach, Queensland, 22‐24 October 2014. | ||||||
| Measurements or Duration: | 1 pages | ||||||
| Additional URLs: | |||||||
| DOI: | 10.1111/jgh.12736 | ||||||
| ISSN: | 0815-9319 | ||||||
| Pure ID: | 59436673 | ||||||
| Copyright Owner: | Consult author(s) regarding copyright matters | ||||||
| Copyright Statement: | This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au | ||||||
| Deposited On: | 29 May 2020 01:01 | ||||||
| Last Modified: | 30 Jul 2024 14:41 |
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