Targeting epigenetic modifiers in breast cancer
Casciello, Francesco (2020) Targeting epigenetic modifiers in breast cancer. PhD thesis, Queensland University of Technology.
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Francesco Casciello Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
Environmental factors in within tumours are known to affect cancer progression and behaviour. In solid tumours, hypoxia (a low-oxygenated state) is a common condition associated with a more aggressive disease and with an increased risk of metastasis. This project focused on evaluating the potential of blocking an epigenetic enzyme, G9a, in breast cancer. The presented work demonstrates that G9a is crucial for the hypoxic response in cancer and that its inhibition is effective in reducing cancer cell survival and blocking metastatic formation. Overall, the described work represents a proof-of-concept demonstrating that G9a is a promising therapeutic target in breast cancer.
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| ID Code: | 200821 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Lee, Jason, Richard, Derek, O'Byrne, Ken, & Pollock, Pamela |
| Keywords: | G9a, Hypoxia, Breast cancer, Metastasis, EZH2, CDH10 |
| DOI: | 10.5204/thesis.eprints.200821 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 10 May 2022 09:52 |
| Last Modified: | 24 Jan 2025 00:44 |
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