Sequential MRI reveals vertebral body wedging significantly contributes to coronal plane deformity progression in adolescent idiopathic scoliosis during growth

Labrom, Fraser R., , , , , , , & (2020) Sequential MRI reveals vertebral body wedging significantly contributes to coronal plane deformity progression in adolescent idiopathic scoliosis during growth. Spine Deformity, 8(5), pp. 901-910.

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Description

Study design: Cross-sectional study. Objectives: To provide a comprehensive, multi-stage investigation of vertebral body (VB) and intervertebral disc (IVD) coronal plane deformities for adolescent idiopathic scoliosis (AIS) patients with a main thoracic curve type, using a series of sequential magnetic resonance images (MRIs). Summary of background data: Despite numerous investigations of AIS deformity at the spinal segmental level, there is little consensus as to the major contributor to the lateral curvature of a scoliotic spine. Moreover, scoliotic deformity is often described along a continuum of progression, with few studies having characterised the change in segmental deformity for AIS patients whose deformity progresses clinically over time. Methods: 30 female AIS patients with primary thoracic curves were included between 2012 and 2016. Three sequential MRIs were captured for each patient. Datasets were reformatted to produce true coronal plane images of the thoracic spine (T4–L1). Overall curve morphology, coronal plane IVD and VB segmental deformity and rates of growth were analysed. Results: Right-side asymmetry was greater in IVDs (18.5 ± 23.9%) when compared to VBs (8.3 ± 9.2%) (P ' 0.05) by third scans. Despite this, 77% of patients demonstrated the majority (' 50%) of their coronal curvature was attributed to VB wedging when measured across all three scans. Regardless of progression status, scan number, or region, the sum of the VB wedging angle was greater than the sum of the IVD wedging angle (all P ≤ 0.05). There was no correlation between the rates of major curve angle progression and standing height increase, VB height growth, or IVD height growth (P ' 0.05). Conclusions: VB wedging contributed more to the lateral deformity observed in primary thoracic subtypes of AIS patients than IVD wedging. While IVDs demonstrated the greatest asymmetric deformity, their relatively smaller height resulted in a smaller proportional change in lateral curve angle compared to the VBs. Level of evidence: IV.

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17 citations in Scopus
16 citations in Web of Science®
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ID Code: 201854
Item Type: Contribution to Journal (Journal Article)
Refereed: Yes
ORCID iD:
Izatt, Maree Torcid.org/0000-0002-4926-3077
Contractor, Prathmeshorcid.org/0000-0002-8572-2015
Grant, Caroline Aorcid.org/0000-0002-5128-9903
Pivonka, Peterorcid.org/0000-0001-9183-530X
Askin, Geoffrey Norcid.org/0000-0002-1734-0082
Little, J Paigeorcid.org/0000-0001-8377-5343
Measurements or Duration: 10 pages
Keywords: adolescent idiopathic scoliosis, AIS, MRI, scoliosis progression, vertebral body wedging, intervertebral disc wedging, MR imaging, sequential MRI
DOI: 10.1007/s43390-020-00138-w
ISSN: 2212-134X
Pure ID: 59748025
Divisions: Current > Research Centres > Centre for Biomedical Technologies
Past > Institutes > Institute of Health and Biomedical Innovation
Past > QUT Faculties & Divisions > Science & Engineering Faculty
Current > QUT Faculties and Divisions > Faculty of Engineering
Current > Schools > School of Mechanical, Medical & Process Engineering
Copyright Owner: Springer
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Deposited On: 10 Jul 2020 02:05
Last Modified: 09 Feb 2025 21:30