Characterization of progressive changes in pedicle morphometry and neurovascular anatomy during growth in adolescent idiopathic scoliosis versus adolescents without scoliosis
Davis, Colin M., Grant, Caroline A., Izatt, Maree T., Askin, Geoffrey N., Labrom, Robert D., Adam, Clayton J., Pearcy, Mark J., & Little, J. Paige (2020) Characterization of progressive changes in pedicle morphometry and neurovascular anatomy during growth in adolescent idiopathic scoliosis versus adolescents without scoliosis. Spine Deformity, 8(6), pp. 1193-1204.
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62340315. |
Description
<p><b>Study design</b>: Prospective cohort study. <br/></p><p><b>Objectives</b>: Investigate the progressive changes in pedicle morphometry and the spatial relationship between the pedicles and neurovascular structures in patients with AIS during growth.<b> <br/></b></p><p><b>Summary of background data</b>: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spine deformity. AIS pedicles are known to be asymmetrical when compared to adolescents without scoliosis. Defining the anatomical changes occurring progressively in scoliosis as it increases with time and growth is essential for understanding the pathophysiology of scoliosis and for treatment planning. MRI is the ideal method to study the growing spine without ionising radiation. <br/></p><p><b>Methods</b>: 24 females with AIS (mean 12.6 years, right sided main thoracic curves) and 20 non-scoliotic females (mean 11.5 years) were selected from an ongoing database. Participants underwent two 3D MRI scans (3 T scanner, T1, 0.5 mm isotropic voxels) approximately 1 year apart (AIS: mean 1.3 ± 0.05 years, control: mean 1.0 ± 0.1 years). The pedicle width, chord length, pedicle height, transverse pedicle angle, sagittal pedicle angle, distance from vertebrae to aorta and distance from pedicle to dural sac were measured from T5 to T12. Inter- and intra-observer variability was assessed. <br/></p><p><b>Results</b>: From scans 1–2 in the AIS group, the dural sac became closer to the left pedicle (p < 0.05, T6, T8–T10 and T12) while the distance from the vertebrae to the aorta increased (p < 0.05, T6–T10). No significant changes in these measurements were observed in the non-scoliotic group. Between scans, the AIS chord length and transverse pedicle angle increased on the left side around the apex (p < 0.05) creating asymmetries not seen in the non-scoliotic cohort. The mean pedicle height increased symmetrically in the non-scoliosis cohort (p < 0.05) and asymmetrically in the AIS group with the right side growing faster than the left at T6–T7 (p < 0.05). <br/></p><p><b>Conclusion</b>: Asymmetrical growth patterns occur in the vertebral posterior elements of AIS patients compared to the symmetrical growth patterns found in the non-scoliotic participants. Level of evidence: Level II prospective comparative study.</p>
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ID Code: | 202214 | ||||||||||||
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Item Type: | Contribution to Journal (Journal Article) | ||||||||||||
Refereed: | Yes | ||||||||||||
ORCID iD: |
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Measurements or Duration: | 12 pages | ||||||||||||
Keywords: | adolescent idiopathic scoliosis (AIS), magnetic resonance imaging (MRI), scoliosis, spine deformity, pedicle height, posterior elements, asymmetrical growth, pedicle morphology | ||||||||||||
DOI: | 10.1007/s43390-020-00160-y | ||||||||||||
ISSN: | 2212-134X | ||||||||||||
Pure ID: | 62340315 | ||||||||||||
Divisions: | Current > Research Centres > Centre for Biomedical Technologies Past > Institutes > Institute of Health and Biomedical Innovation Past > QUT Faculties & Divisions > Science & Engineering Faculty Current > QUT Faculties and Divisions > Faculty of Engineering Current > Schools > School of Mechanical, Medical & Process Engineering |
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Funding Information: | We wish to pay tribute to a valued member of our Spine Research Group, Associate Professor Clayton James Adam who passed away before this manuscript was completed and will be forever missed by the QUT team. No funds were received in support of this work. Partial postgraduate scholarship funding for the first author was provided by Queensland X-Ray Ltd (Australia) and Children’s Health Queensland, Australia. Acknowledgements | ||||||||||||
Copyright Owner: | Springer | ||||||||||||
Copyright Statement: | Accepted Manuscript final author version can be made publicly available 12 months after the official publication date with acknowledgement given to the source and a link inserted to the published article on Springer's website with the following accompanied text:"the final publication is available at link.springer.com". | ||||||||||||
Deposited On: | 20 Jul 2020 01:44 | ||||||||||||
Last Modified: | 13 Feb 2025 08:27 |
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