Tissue engineering of an orthotopic humanised bone-organ as a platform for preclinical multiple myeloma research
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Alvaro Sanchez Herrero Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
This Thesis presents the first steps of the development of a humanized and patient-specific mouse model of multiple myeloma (MM). Novel therapeutic approaches are getting increasingly complex and relevant pre-clinical drug testing is becoming a great challenge. The mouse model presented here features a humanized bone marrow compartment with a humanized bone shell that is able to engraft MM cells and patient-derived hematopoietic stem cells, mimicking myeloma bone disease serving as a unique platform for MM drug testing and discovery.
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| ID Code: | 203046 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Hutmacher, Dietmar W, Juan Pardo, Elena, Mcgovern, Jacqui, & Bray, Laura |
| Keywords: | Mouse model, Tissue Engineering, Multiple Myeloma, Immunotherapy, Humanisation, Stem Cells, Cancer |
| DOI: | 10.5204/thesis.eprints.203046 |
| Divisions: | Past > QUT Faculties & Divisions > Science & Engineering Faculty Current > Schools > School of Mathematical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 13 Sep 2022 05:06 |
| Last Modified: | 13 Sep 2022 05:07 |
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