Heparan sulfate proteoglycans in human models of Neurogenesis

(2020) Heparan sulfate proteoglycans in human models of Neurogenesis. PhD thesis, Queensland University of Technology.

Description

This thesis examined cell surface glycoproteins the heparan sulfate proteoglycans, as regulators of the human nervous system and identified a number of potentially novel stem cell targets for use in treating neurological disorders. Due to the poor outcome of current stem cell transplantation therapies for brain injury and neurodegeneration, this project aimed to understand the fundamentals of human neurogenesis with implications in improving stem cell therapy, understanding brain development, and the factors mediating neurodegeneration.

Impact and interest:

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31 since deposited on 08 Oct 2020
15 in the past twelve months

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ID Code: 203960
Item Type: QUT Thesis (PhD)
Supervisor: Haupt, Larisa & Griffiths, Lyn
Keywords: Heparan Sulfate Proteoglycans, Neurogenesis, Syndecan, Glypican, Stem Cell, BDNF, PDGF, Stem Cell Niche, Neural Progenitor Cells, Mesenchymal Stem Cells
DOI: 10.5204/thesis.eprints.203960
Divisions: Past > QUT Faculties & Divisions > Faculty of Health
Past > Institutes > Institute of Health and Biomedical Innovation
Institution: Queensland University of Technology
Deposited On: 08 Oct 2020 07:07
Last Modified: 13 Sep 2022 06:08