Heparan sulfate proteoglycans in human models of Neurogenesis
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Chieh Yu Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
This thesis examined cell surface glycoproteins the heparan sulfate proteoglycans, as regulators of the human nervous system and identified a number of potentially novel stem cell targets for use in treating neurological disorders. Due to the poor outcome of current stem cell transplantation therapies for brain injury and neurodegeneration, this project aimed to understand the fundamentals of human neurogenesis with implications in improving stem cell therapy, understanding brain development, and the factors mediating neurodegeneration.
Impact and interest:
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ID Code: | 203960 |
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Item Type: | QUT Thesis (PhD) |
Supervisor: | Haupt, Larisa & Griffiths, Lyn |
Keywords: | Heparan Sulfate Proteoglycans, Neurogenesis, Syndecan, Glypican, Stem Cell, BDNF, PDGF, Stem Cell Niche, Neural Progenitor Cells, Mesenchymal Stem Cells |
DOI: | 10.5204/thesis.eprints.203960 |
Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation |
Institution: | Queensland University of Technology |
Deposited On: | 08 Oct 2020 07:07 |
Last Modified: | 13 Sep 2022 06:08 |
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