Probing the role of methionine oxidation in substrate and inhibitor interactions with native and recombinant Human Neutrophil Elastase
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Darren Leahy Thesis
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Available under License Creative Commons Attribution Non-commercial No Derivatives 4.0. |
Description
This thesis was an exploration of how Human Neutrophil Elastase (HNE) activity can be modulated by oxidation of methionine residues located on substrates and inhibitors. Research focused on producing a molecular toolbox of innovative HNE substrates and inhibitors specifically engineered to include methionine, then assessing the mechanism by which oxidation leads to targeted interaction with HNE. This may be an important biochemical process in chronic obstructive pulmonary disease, which is linked to HNE destruction of elastic lung tissue together with oxidative damage by cigarette smoke and neutrophil-mediated inflammation.
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| ID Code: | 204141 |
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| Item Type: | QUT Thesis (PhD) |
| Supervisor: | Harris, Jonathan & Peake, Jonathan |
| Keywords: | human neutrophil elastase, methionine sulfone, methionine sulfoxide, chronic obstructive pulmonary disease, recombinant protein, solid phase peptide synthesis, substrate, inhibitor, oxidation, serine protease |
| DOI: | 10.5204/thesis.eprints.204141 |
| Divisions: | Past > QUT Faculties & Divisions > Faculty of Health Past > Institutes > Institute of Health and Biomedical Innovation Current > Schools > School of Biomedical Sciences |
| Institution: | Queensland University of Technology |
| Deposited On: | 08 Oct 2020 07:09 |
| Last Modified: | 08 Oct 2020 07:09 |
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